Background: Rotavirus infection, a frequent cause of death in developing countries is also known to be the leading cause of acute gastroenteritis requiring hospitalization in infants and young children in the developed world. In this study, the most prevalent serotypes of rotavirus in Tehran and seasonal distribution in a year were investigated. Materials and methods: Fecal samples were collected from a total of 180 infants and children with acute gastroenteritis in two children's hospitals in Tehran. The samples were tested by ELISA. Serotyping investigation of viral specimens was performed, using 7 serotypes monoclonal antibodies (G1-G2-G3-G4-G6-G8-G9) in ELISA tests. Results: Rotavirus type A was detected in 66 samples (37%). G1 and G4 serotypes were the most common serotypes found in infected children and infants in Tehran. The peak of rotavirus infection prevalence occurred during the cold months of the year. Conclusion: This study underlines the importance of these serotypes in the etiology of severe diarrhea in children. G1 and G4 serotypes were the most common serotypes.

Keywords: Rotavirus, Serotype, Children

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