Abstract Background: Meningioma is the most common CNS tumor association of this tumor with specific markers P53, Ki67 has been reported in some studies. This study was done with the aim of determining the frequency of these markers in patients presenting with meningioma in a teaching hospital in Tehran. Materials and methods: This cross-sectional study was done on samples obtained from all patients operated for meningioma in Shohadae Tajrish Hospital from 1996 to 2011. Meningiomas were graded in accordance with the WHO grading system. This method was performed by tissue microarray on paraffin embedded blocks of the samples several pin-size samples were placed on a single glass slide and immune-histo-chemistry study was done for Ki67 and P53 markers. Results: Study done on 89 paraffin embedded blocks of meningiomas revealed that 43.82% were grade 1, 44.94% grade 2, 3.37% grade 3, and 4.49% of meningiomas had atypical features while 3.37% had invaded the brain. Expression of P53 was seen in 31.28% of meningiomas in grade 1, 57.77% in grade 2, 60% in grade 3, 47.5% in tumors with atypical features and in 65% of tumors invading the brain (P= 0.087(. Expression of Ki67 was observed in 7.46% of grade 1, 33.5% of grade 2, 22.5% of grade 3, 10.78% of meningiomas with atypical features and 20% of tumors invading the brain (P= 0.032 ). Conclusion: It seems that there is a relationship between the grade of meningiomas and expression of Ki67 in tumor cells. Keywords: Meningioma, Ki67, P53, Tissue microarray.

Keywords: Meningioma, Ki67, P53, Tissue microarray.

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