Background: Previous studies have shown that impulsive or uncontrolled behaviors in addicts to obtain the drug and drug abuse may be due to overcome one of the brain/behavioral systems. In this study we sought to answer the question whether the overcoming can be associated with relapsing or not? Materials and methods: The method of research was causative-comparative. To achieve our aim, we categorized addicted people with relapse and non-relapse in two groups, each group comprising 31 subjects were selected by available sampling method and evaluated on Gray-Wilson personality questionnaire. Data analysis has been done for comparison on each independent group by T Test. Results: The results, indicated that behavioral activation system and fight subscale in addicts with relapse was significantly different with (greater than) non-relapse people. The behavioral inhibition system, was not significantly different in two groups. Conclusion: Results showed, specific biological characteristics can be considered as risk factors for addiction, moreover, in the field of prevention and treatment, consideration of these characteristics and sensitivities are very useful.