Volume 42, Issue 4 (12-2018)                   Research in Medicine 2018, 42(4): 196-201 | Back to browse issues page

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Alzahra University , f.kazemi@alzahra.ac.ir
Abstract:   (1009 Views)
Background: Obesity is associated with increased risk of many diseases. Methylation is an important factor in obesity, indicating epigenetic changes. However, there is lack of data about PGC-1α methylation and regular exercise. Purpose of this study was to determine effects of 6-week high-intensity interval training (HIIT) on PGC-1α methylation in gastrocnemius muscle of obese male rats.
Methods: In a experimental study, twenty four male Wistar rats were randomly divided into 4 groups (6 rats each): control healthy, trained healthy, control obese and trained obese. Healthy group consumed normal diet and obese group consumed high-fat diet (for 6 weeks). Trained healthy and trained obese performed swimming HIIT for 6 weeks. 24 hours after the last session of the training, gastrocnemius muscle of control and trained rats was extracted and then afterwards PGC-1α methylation was assayed. For analyzing data, paired sample t-test and one-way analysis of variance were used.
Results: After 6 weeks, body weight of trained obese group compared with control obese was decreased significantly (P=0.021). In addition, after 6-week HIIT, PGC-1α methylation of healthy (P=0.010) and obese group (P=0.037) compared with their control group was decreased significantly.
Conclusion: It appears that 6-week swimming HIIT can be effective on obesity state and significantly reduce PGC-1α methylation in gastrocnemius muscle of obese male rats.
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Type of Study: Original |
Received: 2018/05/27 | Accepted: 2018/08/7 | Published: 2019/01/28