Volume 44, Issue 2 (6-2020)                   Research in Medicine 2020, 44(2): 360-365 | Back to browse issues page

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Abstract:   (2272 Views)
Backgroundm: Exercise training and antioxidant consumption is one of the important factors in preventing the sarcopenia and apoptosis in aging muscles. The aim of the presenstudy was to investigate the effects of aerobic exercise and vitamin D supplementation on apoptosis and sarcopenia in aging rats.
Materials and methods: In the current experimental study, 50 aging rats (Age: -22-20month old; Weight: 20±220 g) were randomly divided into five groups of 10 rats: control(C), Salin (S), vitamin D(VD), training (T), and vitamin D + training (VDT). Exercise groups ran on treadmill four days a week for eight weeks with a specific speed and %10 incline and received .05 vitamin D injection on a daily basis. BAX , BCL2-, follistatin, and myostatin proteins were assessed 24 hr after the last exercise and in anesthetic state on soleus
muscle. All data were analyzed running one way ANOVA and scheffe at the significance level of P<0.05.
Results: BAX and myostatin significantly decreased in VDT and T groups compared to control group (p=0.013 for myostatin and P=0.03 for BAX in VDT group, P=0.017 for myostatin and P=0.027 for BAX in T group). Also, follistatin and BCL2- increased significantly in these groups (P=0.01 for follistatin and P=0.01 for BCL2- in VDT group, P=0.005 for follistatin and P=0.024 for BCL2- in T group). BAX/BCL2-
ratio decreased significantly between groups but no significant difference was observed in myostatin and
follistatin ratio between groups (P>0.05).
conclusion: It seems that eight concurrent aerobic training sessions can decrease apoptosis factors such as BAX and BCL2- and arcopenia consisting of myostatin and follistatin variables in rat muscles and provided that these training be accompanied by vitamin D consumption, it may result in prevention of muscle apoptosis and sarcopenia in aging rats.
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Type of Study: Original | Subject: Physical Education and Sports Science ( Sport physiology- Sport biomecanic
Received: 2019/04/19 | Accepted: 2019/07/30 | Published: 2020/06/20

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