Volume 29, Number 3 (9-2005)                   Research in Medicine 2005, 29(3): 207-211 | Back to browse issues page


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Thyroid function and intellectual development in infant whose mothers receive methimazole. Research in Medicine. 2005; 29 (3) :207-211
URL: http://pejouhesh.sbmu.ac.ir/article-1-22-en.html

Abstract:   (17140 Views)

 Background : Recent studies have shown normal thyroid function in infants whose mothers receive methimazole (MMI) during breast-feeding. This study evaluates the long-term effect of MMI on thyroid function and intellectual development of such children.

Methods : 82 children aged 48-86 months were studied. 42 children had been breast-fed while their thyrotoxic lactating mothers received daily doses of MMI 20-30 mg in the first, 10 mg in the second and 5-10 mg for additional 10 months of therapy. Thyroid function of infants remained normal during the one year of MMI therapy of their mothers. 40 other infants served as controls. Serum T4, T3, and TSH concentrations, urinary iodine, thyroid antibodies, intelligent quotient (IQ), verbal and functional (performance) components (Wechsler and Goodenough tests) were measured in all children of case and control groups.

Results : Height, weight, serum T4, T3, TSH and antithyroid antibody titers were not differed between children of case and control groups. The mean IQ was 107±17 vs 106±16 (Goodenough test) and 103±10 vs 103±16 (Wechsler test) for children of thyrotoxic mothers and control children, respectively. There was no difference in verbal and functional IQ and their components between children of thyrotoxic MMI treated mothers and control children.

Conclusion : Thyroid function and physical and intellectual development of breast–fed infants whose thyrotoxic lactating mothers were treated with MMI are normal at age 48 to 86 months.

Full-Text [PDF 121 kb]   (1381 Downloads)    
Type of Study: General | Subject: General
Received: 2003/01/3

Creative Commons License
This Journal is licensed under a Creative Commons Attribution 4.0 International License  | Research in Medicine

Designed & Developed by : Yektaweb