Volume 10, Issue 3 (March 1986)                   Research in Medicine 1986, 10(3): 145-158 | Back to browse issues page

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Study of Oral Gold ( Auranofin ) in Treatment of Iranian Patient with Rheumatoid Arthritis (RA). Preliminary Report of 6 Months Treatment
Jafar Forghanizadeh , Mohammadreza Sadeghian , Faramarz Ganjian , Mohammad Kheirkhah , Fariba Ahmadi
Department of Rheumatology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract:   (3968 Views)
28 patients with classical / definite RA entered to a prospective open study evaluating efficacy and side effects of Auranofin. 21 patients completed 6 months of therapy with 6 mg Auranofin daily. Parameters of disease activity including Joint Tenderness Score, Joint Swelling Score, Walking Time and duration of Morning Stiffness improved significantly after 6 months (p<0.001). Grip strength, Summated Circumferences of lterphalangeal joints and Erythrocyte Sedimentation Rate did not change. Patient's assessment of global status using visual analogue scale improved. Functional Class changes after 6 months was recorded. Withdrawals were due to: Mucocutaneous side effects in 2. inefficacy in 1, lack of compliance in 2 and loss of follow up in2. we did not seediarrhea, hematological and renal side effects. 
Keywords: Auranofin, Treatment, Rheumatoid Arthritis, Iran
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Type of Study: Original | Subject: Interdisciplinary (Educational Management, Educational research, Statistics, Medical education
Received: 1986/02/10 | Accepted: 1986/06/6 | Published: 1987/03/1
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