Background and purpose: Due to the prevalence of Recurrent Aphthous Stomatitis (RAS) and its complications and the importance of its etiology as well as contradictory reports of the relationship between serum 25-Hydroxyvitamin D levels and RAS, the present study aimed to determine the relationship between serum 25-Hydroxyvitamin D levels and RAS in individuals referred to the Department of Oral and Maxillofacial Medicine at the School of Dentistry of the Islamic Azad University of Tehran in 2018.
Methods and Materials: The study was conducted using a case control method. The samples included 30 patients: 15 patients with RAS and 15 controls. The two groups were matched in terms of age, sex, and inclusion criteria. Exclusion criteria included suffering from systemic diseases, blood diseases, Behcet's disease, autoimmune diseases, iron deficiency, folate deficiency, and vitamin B12 deficiency as well as multi vitamin, iron, calcium, and vitamin D consumption during the past 3 months.
Each volunteer received 5 ml of blood and their serum 25-Hydroxyvitamin D level was determined using HPLC device. The quantitative values, ​​in terms of ng/ml, and their qualitative values, ​​based on normal values, ​​were analyzed statistically running t-test and Fisher's exact test.
Results: Serum 25-Hydroxyvitamin D level in the control group was 85.5 ± 33.59 ng / ml and was 87.33 ±12.65 ng / ml in the case group. In terms of quality, 66.7% in the control group and 40% in the case group had abnormal serum 25-Hydroxyvitamin D levels.
Conclusion: It seems that 25-Hydroxyvitamin D does not seem to play a role in RAS. For more accurate results, furthure studies with larger sample sizes are recommended