Volume 46, Issue 4 (12-2022)
Research in Medicine 2022, 46(4): 111-123 |
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Ethics code: IR.SBMU.REC.1398.152
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Kasravi K, Ghazalian F, Gaeini A, Hajifathali A, Gholami M. A Comparison of Continuous and Discontinuous Aerobic Exercise on the Response of Stem Cells, WBC, and Length of Hospitalization of Candidate Patients of Autologous Hematopoietic Stem Cell Transplantation. Research in Medicine 2022; 46 (4) :111-123
URL: http://pejouhesh.sbmu.ac.ir/article-1-3171-en.html
URL: http://pejouhesh.sbmu.ac.ir/article-1-3171-en.html
Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran. , f.ghazalian@srbiau.ac.ir
Abstract: (676 Views)
Background and Aim: The aim of the present study is to compare two types of aerobic exercise on stem cell mobilization, WBC, and admission durationbefore autologous transplantation. Cancer is a malignancythat causes an uncontrollable growth in the cellreplication. Transplantation of hematopoietic stem cells is required for the treatment of many malignant and non- malignant blood diseases. In hematopoietic stem cell transplantation, patients' hematopoietic cells are removed and replaced with stem cells. The success of the transplantation depends largely on the amountof stem cells. The higher the number of cells, the sooner recovery happens.
Methods: In a quasi- experimental applied study, 60 patients in the age range of 22-69 years admitted to Taleghani Hospital were randomly selected and assigned into 3 groups of 20 members (continuous aerobic, discontinuous aerobic, and control group). The aerobic exercise program was performed for 7 consecutive days of mobilization period including walking on a treadmill (according to the patient's ability) continuously and discontinuously for 30 minutes in the morning and afternoon, taking into account the perceived effort. Blood samples were taken in the mornings before and after mobilization, and the CD34-MNC and WBC levels were counted as absolute. Days of admission were counted after discharge. Chi-square test, analysis of covariance (ANCOA), and multiple comparison test were used for statistical analysis. The p-value of 0 ≤ 0.05 was considered significant.
Results: Moderate- intensity continuous and discontinuous aerobic activity increases the number of CD34- MNC and WBC countin all 3 groups and decreases the days of admission in the continuous group. . Moreover,the amount of CD34 and MNC cells in the continuous aerobic activity group was significantly higher than in the discontinuous aerobic activity group. (This case has been published in an article in English that is mentioned in the references). However, WBC count was not significantly different between the continuous and discontinuous groups. Finally, the days of admission in continous group were less than the discontinuos group (P≤0.05).
Conclusion: Moderate- intensity continuous and discontinuous aerobic exercise significantly increases hematopoietic stem cells. The admission period in thecontinous group was less than the discontinuos group. However, the increasing rate of cell count and the decreasing rate of admission period in the continuous group were higher than the discontinuous group. Due to the role of these cells in the transplantation our findings could contribute to a higher rate of success.
Methods: In a quasi- experimental applied study, 60 patients in the age range of 22-69 years admitted to Taleghani Hospital were randomly selected and assigned into 3 groups of 20 members (continuous aerobic, discontinuous aerobic, and control group). The aerobic exercise program was performed for 7 consecutive days of mobilization period including walking on a treadmill (according to the patient's ability) continuously and discontinuously for 30 minutes in the morning and afternoon, taking into account the perceived effort. Blood samples were taken in the mornings before and after mobilization, and the CD34-MNC and WBC levels were counted as absolute. Days of admission were counted after discharge. Chi-square test, analysis of covariance (ANCOA), and multiple comparison test were used for statistical analysis. The p-value of 0 ≤ 0.05 was considered significant.
Results: Moderate- intensity continuous and discontinuous aerobic activity increases the number of CD34- MNC and WBC countin all 3 groups and decreases the days of admission in the continuous group. . Moreover,the amount of CD34 and MNC cells in the continuous aerobic activity group was significantly higher than in the discontinuous aerobic activity group. (This case has been published in an article in English that is mentioned in the references). However, WBC count was not significantly different between the continuous and discontinuous groups. Finally, the days of admission in continous group were less than the discontinuos group (P≤0.05).
Conclusion: Moderate- intensity continuous and discontinuous aerobic exercise significantly increases hematopoietic stem cells. The admission period in thecontinous group was less than the discontinuos group. However, the increasing rate of cell count and the decreasing rate of admission period in the continuous group were higher than the discontinuous group. Due to the role of these cells in the transplantation our findings could contribute to a higher rate of success.
Type of Study: Applicable |
Subject:
Physical Education and Sports Science ( Sport physiology- Sport biomecanic
Received: 2022/04/8 | Accepted: 2022/07/17 | Published: 2023/02/15
Received: 2022/04/8 | Accepted: 2022/07/17 | Published: 2023/02/15
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