Volume 31, Issue 3 (10-2007)                   Research in Medicine 2007, 31(3): 297-289 | Back to browse issues page

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, allameha@modares.ac.ir
Abstract:   (12811 Views)
Cyclooxygenase (COX) is the key enzyme required for the conversion of arachidonic acid to prostaglandins. Two cycloxygenase isoforms have been identified and are referred to as COX-1 and COX-2. Both enzymes are blocked by nonselective anti-inflammatory drugs (NSAID), such as indomethacin and ibuprofen. COX-1 is an enzyme normally found in tissues and is involved in physiological functions, while COX-2 is an acute phase reactant associated with inflammation. Recently, COX-2 has been found to be associated with hyperalgesia, angiogenesis, cancer and Alzheimerُs disease. The suggestion that COX-2 is causally linked to cancer offers a new approach to extending our knowledge about the neoplastic phenomenon and improving management of human malignant diseases.
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Type of Study: Review |
Received: 2008/04/19 | Published: 2007/10/15

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