Background: Although postoperative pain has been suitably controlled by new analgetic agents, it is still a major health concern following the operation. The present study was designed to compare the analgetic effect of indomethacin suppository and intramuscular pethidine in post cesarean section period. Materials and methods: For this randomized controlled clinical trial, 204 women subjected for elective or emergency cesarean section were enrolled. They were randomly assigned in 3 groups indomethacin suppository 200mg (68 subjects), intramuscular pethidine 50mg (68 subjects), and placebo (68 subjects). Response to therapy was assessed by Visual Analog Scale (VAS) during the first hour and 8 hours following the second and third dose. Results: Results revealed a significant pain relief following the first and second dose of indomethacin when compared with placebo and pethidine groups (p<0.05). Meanwhile, pain was significantly relieved 4 hours following the first and second dose of pethidine when compared with placebo, however, the effect was even greater 8 hours later. Conclusions: Indomethacin suppository could effectively relieve pain during the first day following the cesarean section.

Keywords: Indomethacin suppository, Cesarean section, Pethidine.

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