Frequency of helicobacter pylori among patients with diabetes mellitus : Research Center for Gastroenterology and Liver Disease, Shaheed Beheshti University of Medical Sciences Abstract: Background: It is believed that diabetes mellitus (DM) increase the susceptibility to Helicobacter Pylori (HP) infection, but there is little information about the role of DM in being infected patients with HP. We studied the frequency of HP in diabetic patients referred to Taleghani hospital during 2003-2004. Materials and methods: In this case–control study, frequency of HP in diabetic patients referred to Taleghani hospital were studied. Case group consisted of 84 patients with documented diabetes mellitus and control group included dyspeptic patients without DM who were been matched to the case group. Both case and control groups underwent endoscopy. Patients who had history of using antibiotics during the previous month or proton pump inhibitors during the past week were excluded. Urease test was performed in all patients. In negative unease test, biopsy was taken to evaluate histologic study of HP. Results: Mean age of case and control groups were 47.5±10.2 and 47.6±10 years, respectively. In both groups, male to female ratio was 46 to 36. Nineteen patients (22.6%) have diabetes type1 and others (77.4%) have diabetes type 2. Frequency of HP in case and control groups were 47 (51.1%) and 45 (48.9%), respectively and there was no significant differences between two groups. Odds ratio for being infected with HP in diabetic patients was 0.95 (95% CI: 0.7 – 1.3). Conclusion: This study didn’t demonstrate any relation between DM and HP in adult patients. So, high frequency of dyspepsia in diabetic patients can be attributed to other factors such as autonomal disorders. KEYWORDS: .

Keywords: Helicobacter pylori, Diabetes Mellitus, Dyspepsia, Endoscopy

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