Volume 33, Number 1 (5-2009)                   Research in Medicine 2009, 33(1): 31-34 | Back to browse issues page


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Ghotbi F, Tghiloo M, Gashb A2. The effect of Clofibrate on neonatal jaundice. Research in Medicine. 2009; 33 (1) :31-34
URL: http://pejouhesh.sbmu.ac.ir/article-1-599-en.html

Abstract:   (21305 Views)
Abstract: Background: Hyperbilirubinemia is a common problem in newborn infants and may progress to kernicterus if not treated. The objective of this study was to determine the therapeutic effect of clofibrate in full-term healthy neonates with non-hemolytic hyperbilirubinemia. Material and method: A randomized clinical trial was performed on two groups of healthy full-term neonates with jaundice. Clofibrate group, (n=50), received a single dose of oral clofibrate (100mg/kg), plus phototherapy, while the control group (n=50), received only phototherapy. Results: The mean plasma total bilirubin levels at 12, 24, and 48 hours after treatment were significantly lower in the clofibrate treated group, as compared with the control group (p=0.001). At 48 hours of treatment, 48% of patients in the clofibrate group, had bilirubin levels <12 mg/dl in comparison with 16% of control group (p=0.001). Treatment with clofibrate also resulted in a shorter duration of hospital stay as compared to the control group (p=0.001). Conclusion: A single oral dose of clofibrate (100mg/kg), along with phototherapy is more effective than phototherapy alone in treatment of non-hemolytic hyperbilirubinemia in full-term healthy newborn infants. KEYWORDS: Neonatal jaundice, Clofibrate, Non-hemolytic hyperbillirubinemia, RCT.
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Type of Study: Original | Subject: Pediatrics
Received: 2009/10/3

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