Abstract Background: Hemostasis has turned into one of the major concerns in surgery and anesthesia. Anesthesiologists are always pursuing new methods and medications to avoid allogenic and autologous blood transfusion. The present study aimed at examining the effects of tranexamic acid on the reduction of hemorrhage and the need for transfusion. Methods: A sequential controlled clinical trial was performed on 60 patients referred to Imam Hossein Hospital, with femoral fracture, aged between 20 to 50, and with no coexisting diseases. The patients were divided into trial and control groups of 30 each. Prior to the surgery, the trial group received 10mg/kg dose of Tranexamic acid. Results: There were significant differences between the two groups with the average blood loss in trial group 675±208.7cc and in control group 998.4±230.9cc. In trial group, 5 patients and in control group 14 patients received Allogenic blood in which the difference was also statistically significant (P<0.02). Conclusion: It is concluded that the use of Tranexamic acid reduces operational hemorrhage and blood transfusion during femoral fracture surgery. Further evaluation of safety is required before recommending the use of antifibrinolytics in orthopedic surgery.

Keywords: Orthopedic surgery, Hemorrhage, Tranexamic acid, Transfusion.

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