Volume 33, Number 3 (Autumn 2010)                   Research in Medicine 2010, 33(3): 179-182 | Back to browse issues page


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Mofid1 B, Eshraghi2 P, Daneshpour2 M S, Hedayati M. PTEN polymorphism (IVS4) in breast cancer in Iranian women. Research in Medicine. 2010; 33 (3) :179-182
URL: http://pejouhesh.sbmu.ac.ir/article-1-665-en.html

, Hedayati@endocrine.ac.ir
Abstract:   (10707 Views)
Abstract Background: Inactivation of tumor suppressor genes can cause irreversible uncontrolled growth. PTEN is a tumor suppressor gene and its polymorphism (IVS4) role in breast cancer was investigated in this study. Methods: Forty nine female subjects with confirmed breast cancer comprised the case group and 43 healthy women participated as a control group in this study. The PTEN polymorphism was genotyped by amplification of genomic DNA and then digestion by restriction of endonuclease and finally RFLP analysis. Results: The frequencies of mutant allele (M) were 0.37 and 0.27, respectively in the case and control groups. The genotype frequency distributions were in Hardy-Weinberg equilibrium in both groups. Conclusion: The mutant allele frequency in case group was 10% higher than control group it is possible that PTEN IVS4 polymorphism has a role in Breast Cancer. KEYWORDS: PTEN, IVS4, Breast Cancer, polymorphism.
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Type of Study: Original | Subject: General
Received: 2010/02/23

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