Volume 35, Issue 2 (6-2011)                   Research in Medicine 2011, 35(2): 114-118 | Back to browse issues page

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Department of Infectious Diseases, The infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran , yadegarynia@yahoo.com
Abstract:   (18336 Views)
Abstract Background: Hepatitis B is one of the most prevalent chronic and persistent hepatitis infections which may lead to chronic hepatitis and hepato-cellular carcinoma. Since hospital personnel are more susceptible to hepatitis B this study was done to determine the relation between number of hepatitis B vaccinations and the presence of anti HBS antibody in personnel working in a large hospital in Tehran. Methods: This was a cross-Sectional study conducted in 2010 on 530 personnel working in Khatam-ol-Anbiya Hospital. Blood samples were collected from the subjects selected through convenience sampling and the level of anti-HBS antibody checked: antibody levels >10 mIU/ml were considered to be protective. Results: Antibody levels were less than the stated cut-off in 78 individuals, (14.7%). Mean antibody levels were 9.5 mIU/ml in the 27 unvaccinated persons 86.6 mIU/ml in 7 individuals who had received the vaccine only once 160 mIU/ml in the 32 who had been vaccinated twice 192 mIU/ml after 3 doses of the vaccine in 276 persons and in the 58 subjects who had received >3doses, the mean level of the antibody was 321 mIU/ml, (p=0.001). Conclusion: Anti-HBS antibody levels show a significant rise after repeated vaccinations. Keywords: Hepatitis B, vaccinations Anti HBs, Medical personnel
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