In this paper, we report a rare case who is a twenty-six years old woman with extramedullary organ involvement of multiple myeloma. The initiation of disease was solitary plasmacytoma in the second vertebra of the lumbar spine that received radical radiotherapy and then she underwent chemotherapy for one year with the diagnosis of multiple myeloma after expanding lesion to the bones and adjacent soft tissue, the bone lesions received palliative radiation because of threatened fracture. About there months later she found out multiple masses in her both breasts. The report of fine needle aspiration (FNA) was involvement of both breasts by multiple myeloma then she underwent palliative radiation to the breasts. Involvement of the breast by extramammary neoplasm is rare. Clinically and radiologically, secondary neoplastic masses may mimic primary benign and malignant neoplasm of the breast. A correct pathologic diagnosis of the breast mass is of considerable importance since the treatment of the primary and secondary malignancies of the breast is different. FNA is an invaluable method in differentiation of these two entities.

Keywords: Multiple myeloma, Secondary neoplastic massed of the breasts, Fine Needle Aspiration.

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