Background: For conservation and continuous of educational, occupational and social performance, the well-being is the goal of mental health and providing information and statistical data in relation to mental  disorders are the original requirements for mental health policies. The present study was conducted to determine the prevalence of mental disorders in interns of Shahid Beheshti university of medical sciences  during a 6-month period.

 Materials and methods: For this descriptive study, 2 separate questionnaires, one dealing with demographic and the other GHQ-28 were completed. Results were compared in two groups of healthy and suspicious  subjects according to the sex, marital status, living places before entering university, present living places,  hopefulness to career, economic status, presence of underlying disease, abuse of substances (alcohol, opium, and canabis), and tendency to marriage.

 Results: Result showed that at the cut off point of 22 for men and 21 for women, 52.1% of the interns were suspicious to have any kind of mental disorders. Mental disorders were more frequently reported among females, married interns, interns living in rental house, non interested interns to medicine, disappointed  interns to their career, low economic status subjects, interns with underlying disease, and substance abusers.  Of these, female sex, lack of interest, disappointing, low economic status, and underlying disease have shown sign in cant association with menta! disorders. 

Conclusion: Mental disorders are quite common among these interns. Our data can be used as a statistical  source to plan for mental health policies.