Volume 41, Issue 2 (7-2017)                   Research in Medicine 2017, 41(2): 63-70 | Back to browse issues page

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roozbakhsh M, Farhadinasab A, Motamedi F. The comparison effect between Haloperidol and Midazolam & plassebo in Delirium treatment on adult male rat based on behavioural changes. Research in Medicine. 2017; 41 (2) :63-70
URL: http://pejouhesh.sbmu.ac.ir/article-1-1717-en.html
دانشگاه علوم پزشکی شهیدبهشتی , maliheroozbakhsh@gmail.com
Abstract:   (6222 Views)

purpose: Delirium is change in consciousness and ability to focus and attention . it is reducing costs and increasing the time patients stay in hospital . While sedative  and hypnotic drugs reduce pain and anxiety , but according to sources , it is one of the risk factors of delirium . Haloperidol because of low anticholinergic activity and low drug interactions and metabolites have more therapeutic use.        
Materials and Methods: this search is experimental method,90 rats were studied . Biperiden 40 mg / kg to 42 mice and LPS 50µg/kg was administered to 42 mice . Delirium confirmed by studying the behavior of mice for 60 minutes. The control group consisted of 6 mice . Compare the dose and effect of haloperidol and midazolam on treatment of delirium in  treatment groups by studying the behavior of delirium in 30 minutes after injection were  studied (p≤0.01in haloperidol group0.2mg/kg compromise withmidazolam0.5mg/kgand1mg/kg)  . Kruskal-Wallis test and man_u_witney post test were analized.                         .
Results: findings are: created  deliriumin this study was: 16% hyperactive , 20% hypoactive and  other were mixed . Both drugs haloperidol and midazolam were effective on hyperactive standards of behavior((p≤ 0.05in haloperidol group0.1mg/kg and midazolam 0.25mg/kg) . Haloperidol in low doses were effective on hypoactive delirium and 0.5 mg / kg dosage had no significant effect .  Midazolam in this case was significant on  at low doses but  1mg / kg dosage worse  this situation .

Conclusion: The findings of this study shows the importance of early diagnosis and treatment of delirium especially hypoactive type because of improper treatment worsens  (high-dose midazolam) prognosis patient's and condition

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Type of Study: Applicable |
Received: 2017/02/21 | Accepted: 2017/05/24 | Published: 2017/08/9

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