Background and Aim: Infertility is an active disability. Male factors account for 50% of infertility cases. Disruption of sperm function and damage to spermatogenesis are among of the most common causes of male infertility. Anatomical trauma or anatomical defects in the reproductive system and the use of drugs to treat diseases can disrupt the production of sperm and infertility in men. The purpose of the present study was to evaluate the effect of diazepam on fertility in men.

Materials and Methods: A total of 30 male Wistar rats, weighing 200-250 g, were selected and randomly divided into 5 groups of 6: control and treatment groups with injectable doses of 2 mg/kg, 3 mg/kg, 4 mg/kg, and 1 mg/kg5, and the injections were proportional to the weight of the rats, in the amount of 0.18 ml / 0, 1.0 ml / ml, 0.16 ml / ml, and 0.2 ml / ml. Serum physiology was injected for the control group. Then, the anesthetized rats, testicular, vas deferens, and epididymis were examined for examination, testis, sperm motility, and live sperm count. The results were analyzed using Minitab and Anova tests with significance level set at P <0.05.

Results: The results of weight control showed that large and small testicles, percentage of sperm, and sperm count with forward mobility, compared with those of control group decreases in injectable groups at a dose of 3 mg / kg in all factors other than the number of sperm with forward mobility. In other groups, only testicular weight decreased significantly in mg / kg2 (P <0.01).

Conclusion: According to the results, it seems that diazepam with injectable dose of 3 mg / kg had a decreasing effect on the effective parameters on fertility.

Keywords: Diazepam, testes, Fertility.

Full-Text [PDF 444 kb]   (3163 Downloads)