Volume 44, Issue 2 (6-2020)                   Research in Medicine 2020, 44(2): 395-400 | Back to browse issues page

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abooali E, salehi M. A study to prevalence of helicobacter pylori infection in patients with non-alcoholic fatty liver in Loqhman hospital in 2017-2018. Research in Medicine. 2020; 44 (2) :395-400
URL: http://pejouhesh.sbmu.ac.ir/article-1-2059-en.html
Shahid Beheshti Medical University , elahe.abooali@gmail.com
Abstract:   (2266 Views)
 
Background: Helicobacter pylori infection is known as an important risk factor in the development of ulcer,
gastritis, and malignancy. However, recently, the systemic effect of H. pylori infection on other organs, such as
infection of liver and development of non-alcoholic fatty liver disease, has been found. The prevalence of HPI
in NAFLD patients has been noted, as the prevalence of NAFLD is growing worldwide. The aim of the present
research was to determine the prevalence of H. pylori in NAFLD patients. Then, in case of positive relationship,
through the easy and inexpensive control and treatment of H. pylori, it is possible to prevent development of
NAFLD whose prevalence is increasing.
Materials and methods: A descriptive cross sectional study was carried out. NAFLD patients referring to
Digestion clinic of Loghman Hakin hospital were chosen using available sampling. After confirmation of NAFLD
via ultrasound, serology test of H. pylori antibody (IgG) was requested. Then, the collected data were coded
and introduced into computer. The quantitative data are described using mean and standard deviation, while
the qualitative data are described by frequency and percentage. Chi2 and independent t-test were used for data
analysis. The prevalence was determined by confidence interval %95, and the statistical tests were performed
at significance level of %5.
Results: In the present study, 181 NAFLD patients were tested. The mean age of the patients was 11.95±44.15
years (male= %38.7( 70); female= %61.3( 111)). One patient (%0.55) from the NAFLD group was Grade IV, 15
%8.29() were grade III, %28.18( 51) Grade II, and most of the patients (%63 ,114) were Grade I. H. pylori was
positive among 114 patients (%63). The prevalence rates of positive IgG test among women and men were %64
and %61.4, respectively. No significant difference was observed in IgG test prevalence between men and women
(p=0.731). No significance difference existed between the age of patients in terms of IgG test results, either
(p=0.441). Although the prevalence of H. pylori was less in non-smokers, no significant difference was observed
in the prevalence of H. pylori in terms of smoking status. Finally, no significant difference was observed between
the two groups in terms of BMI (p=0.437).
Conclusion: Our study indicated that the prevalence of H. pylori is relatively high in NAFLD patients. This high
prevalence can be a cause for the possible relationship between H. pylori and NAFLD.
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Type of Study: Original | Subject: Internal medicine: (glands, lungs, digestion, kidneys, blood, rheumatology,Geriatrics )
Received: 2019/06/16 | Accepted: 2019/07/31 | Published: 2020/06/20

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