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, Islamic Azad University, Mashhad Branch, Mashhad, Iran , maryam_tehranipour@mshdiau.ac
Abstract:   (686 Views)
Background and Objective :Type 1 diabetes or insulin-dependent diabetes mellitus is caused by a lack of insulin secretion caused by the destruction of beta-pancreatic cells. The genus Perovskia-L belongs to the Persian mint family, with pharmacological effects such as analgesic, anti-inflammatory, treatment of infection and so on. The aim of this study was to evaluate the effect of Extract of Bromelaceae on blood glucose and biochemical factors in male diabetic rats..
Materials and Methods: In this experimental study 60 male Wistar rats weighing 200-250 g were randomly divided into 10 groups of 6 rats each: control, healthy receiving glibenclamide, healthy treated with 150, 300 and 600 mg / kg. Body extracts of diabetic rats, diabetic control (hyperglycemia), positive control (hyperglycemia treated with glibenclamide), hyperglycemia treated with 150, 300, and 600 mg / kg body weight of extract were divided into two groups. After 14 days of gavage, blood samples were taken from the animals and biochemical factors such as glucose, insulin, triglyceride, cholesterol and LDL-cholesterol were measured.
Result The results showed that the hydroalcoholic extract of Bromzebal reduced the mean glucose in the diabetic group from 234 ± 11 to 140 ±5  in the treated diabetic groups and the mean cholesterol from 114± 2  to 80± 5  and the mean triglyceride from 114 ± 3 to 70 ± 14. And reduced LDL from 82 ±2 to 44±5.Hydroalcoholic extract of Bromzebal significantly inhibited increased glucose levels p <0.001, triglycerides p <0.001, p <0.001 cholesterol, and a significant decrease in LDL levels in treated diabetic mice compared with untreated diabetic animals.
Conclusion: It seems that hydroalcoholic extract of Precambrian has a controlling effect on blood sugar and modulates blood biochemical factors in diabetic animals and is likely to be effective in the treatment of diabetes.
     
Type of Study: Original | Subject: Physilogy
Received: 2019/07/12 | Accepted: 2020/06/23

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