For a long period of time some different hypothesis have been published about arteriosclerosis but none of them has discovered the pathogenesis and effective treat­ment of this entity. By elemination of risk factors it is not clear that the disease process stops or reverses. Pre­ventiona and treatment of risk factors should start before manifestation of arteriosclerosis sympthoms. The result of controlling risk factors in adults is 5%-20%, but if this sort of control start at childhood, the result should assess about the age 50-60 revision of hypothesis about arterio­sclerosis are necessary because until we do not recognize this disease process completely and consequently the influence or risk factors on it we will not be able to treat arteriosclerosis effectively and satisfactorily. 
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