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1Cancer Research Center, Faculty of Medicine, Shahid Beheshti Univeristy of Medical Sciences, Tehran, IR Iran , shahpoo2002@yahoo.com
Abstract:   (587 Views)
Background: Breast cancer (BC) is the most common visceral cancer in Iranian women with 13400 new cases annually. A few studies have reported that BC patients with p53 expression had different prognosis and clinical outcome. The aim of the present study is to evaluate and compare clinical outcome and prognostic factors in Iranian breast cancer patients with p53 expression.
Materials and Methods: In a longitudinal study, 801 BC patients who referred and followed by Cancer Research Center from 2003 to 2017, were divided into two groups: 300 patients with p53 expression (positive) and 501 patients without p53 expression (negative). Then clinical outcome and prognostic factors for these two groups were evaluated and compared.
Results: The patients with positive and negative p53 represented 37.5% and 62.5% of whole cases with the mean age 44.2 years (SD=9.4) and 47.7 years (SD=10.9) respectively (p<0.0001). There were more advanced stage and lymph node involvement, more positive lymphovascular invasion and Premenopausal status, higher degrees of negative estrogen receptor (ER) status and positive human epidermal receptor 2 (HER2) expression in patients with positive p53 in comparison to the patients with negative p53 (p=0.0162, p=0.0047, p=0.0296, p=0.0339, p=0.0374 and p=0.0494 respectively). In patients with positive and negative p53, five years disease free survival were 81% and 86.4 %, (p=0.0413) and five years overall survival were 70% and 76.8 %, respectively (p=0.0323).
Conclusion: It seems, better clinical outcome and favorable prognostic factors in patients without p53 expression than patients with p53 expression.
     
Type of Study: Original | Subject: Others
Received: 2020/04/17 | Accepted: 2020/07/18

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