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Department of Dental Materials, Dental School, Shahid Beheshti University of Medical Science, Tehran, Iran. , Hanieh.nojehdehyan@gmail.com
Abstract:   (524 Views)
Abstract
 Background and aim: The use of an occlusive membrane interfacing with gingival connective tissue/epithelium and bone tissue to promote periodontal tissue regeneration has considerable success. The biological basis of tissue-guided membrane regeneration is the addition of a physical barrier prevented the migration of epithelial cells and connective tissue into the lesion to allow periodontal and mesenchymal ligament cells to migrate to the root surface. Existing structures act only as a physical barrier and have no other function. The purpose of this study was to construct and evaluation of a triple-layered composite PCL/ HA membrane containing Dexamethasone loaded PLGA Microspheres to the regeneration of jaw bone in periodontal disease.
 
Materials and Methods: In this experimental study, the composite polycaprolactone-hydroxyapatite membrane along with microspheres containing dexamethasone were prepared by solvent casting. Scanning electron microscopy (SEM) to evaluate morphology, Infrared spectroscopy (FTIR) to study the chemical structure, and spectrophotometry was used to evaluate the release rate of dexamethasone. Except for morphology, 5 samples were prepared and analyzed for each test. The normality of data distribution was evaluated by the Shapiro-Wilk test and the results were evaluated by t-test.
Results: SEM images show that the membranes prepared by this method have high porosity, large and interconnected. Microspheres have an almost uniform surface topography and a completely homogeneous spherical state with an average size of 6 nm to 10 μm. FTIR results confirmed the presence of hydroxyapatite in the structure. Spectrophotometric results showed that the release rate of dexamethasone was higher when the microspheres containing it were in the second layer on the first day (P=0.02), but this amount was not significantly different in the third layer on different days (P=0.12)
Conclusion: It seems that PCL/HA composite membranes were prepared by solvent casting can be used in soft and hard tissue regeneration, due to the similarity to bone tissue and also create suitable conditions for soft tissue repair. 
     
Type of Study: Original | Subject: Physics and Medical Engineering
Received: 2020/09/11 | Accepted: 2020/09/29

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