Volume 46, Issue 3 (9-2022)
Research in Medicine 2022, 46(3): 115-126 |
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Marashi M, Galedari M. Effect of Six Weeks of Interval Training on Expression of Vascular Endothelial Growth Factor in Male Rat High Fat Diet. Research in Medicine 2022; 46 (3) :115-126
URL: http://pejouhesh.sbmu.ac.ir/article-1-3072-en.html
URL: http://pejouhesh.sbmu.ac.ir/article-1-3072-en.html
Department of Exercise Physiology, Faculty of Humanities, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran. , m.galedari@iauahvaz.ac.ir
Abstract: (544 Views)
Background and Aim: VEGF is an important angiogenic factor whose expression and plasma levels are affected by obesity and its effects can be health-promoting or disease-inducing. The aim of the present study was to evaluate the effect of six weeks of interval training on vascular smooth muscle VEGF gene expression in male rats on a high-fat diet. In an experimental study, 40 male rats were randomly divided into four groups: 1) control (standard diet), 2) high fat diet 1 (eight weeks high fat diet), 3) high fat diet 2 (14 weeks high fat diet), and 4) High-fat diet and intermittent exercise. Animals in groups 2 to 5 first ate a high-fat diet (60% of calories from fat) for eight weeks. In the eighth week of the high-fat diet group 1, in order to determine the level of VEGF at the beginning of the training intervention, facilitation and sampling were performed. Periodic training consisted of 5 to 12 60-second runs of 24 to 32 meters per minute and light work intervals of 75 seconds for six weeks (to ensure oxidative compatibility with interval training) and five days a week. Real Time PCR technique was measured. Mann-Whitney test was run to compare the groups.
Results: The results of the present study showed that eight weeks of high-fat diet significantly increased the expression of VEGF gene in vascular smooth muscle of male rats compared to the control group (P =0.001 .(VEGF gene expression was significantly lower after 14 weeks of high-fat diet (P =0.005( compared with that in eight weeks. Also, VEGF gene expression after six weeks of interval training was significantly lower than that in eight weeks of high-fat diet (P = 0.001 (and was not significantly different from the 14-week high-fat and control groups.
Conclusion: Interval training can possibly reduce angiogenesis by reducing VEGF expression in visceral adipose tissue vessels and thus preventing adipose tissue development.
Results: The results of the present study showed that eight weeks of high-fat diet significantly increased the expression of VEGF gene in vascular smooth muscle of male rats compared to the control group (P =0.001 .(VEGF gene expression was significantly lower after 14 weeks of high-fat diet (P =0.005( compared with that in eight weeks. Also, VEGF gene expression after six weeks of interval training was significantly lower than that in eight weeks of high-fat diet (P = 0.001 (and was not significantly different from the 14-week high-fat and control groups.
Conclusion: Interval training can possibly reduce angiogenesis by reducing VEGF expression in visceral adipose tissue vessels and thus preventing adipose tissue development.
Type of Study: Original |
Subject:
Physical Education and Sports Science ( Sport physiology- Sport biomecanic
Received: 2021/07/19 | Accepted: 2022/04/24 | Published: 2023/01/2
Received: 2021/07/19 | Accepted: 2022/04/24 | Published: 2023/01/2
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