Abstract Background: Elaeagnus angustifolia extract has been used for its antinociceptive effects. The present study was done to compare of different dosage of this plant extract with and without Morphine on the extent of the antinociceptive effect. Methods: This study was done on the 80 male NMRI mice with a mean weight of 28±3G. These animals were divided to 10 groups (8 mice in each group) including: control, positive control, group treated with morphine (2 mg/kg), group treated with E. angustifolia aqueous extract (62.5, 125 and 250 mg/kg) and group treated with the plant aqueous extract plus morphine. Study was done on the 80 mice in two stages: with and without morphine and with three dosages of E. angustifolia aqueous extract. The extract was injected through the intraperitoneal route, (i.p) 30 minutes before the writhing test. Normal saline was injected in the control group and indomethacin, (5 mg/kg) to the positive control group. Then, the increase in abdominal pulse was calculated for 30 minutes as a sign of visceral pain and the pulse rates were compared in the different groups. Result: Pulse rate in the control group was 88.4±2.4. These rates were 39.6±2.4 when 62.5 mg/kg E. angustifolia was used without morphine and 9.3±1.4 with same dosage of extract with morphine (p<0.0001). Moreover, our findings showed that antinociceptive effect increased with higher dosages of plant extract (p<0.001). Conclusion: Elaeagnus angustifolia and morphine show evidence of synergistic effect for antinociception in mice. Keywords: Elaeagnus angustifolia, Morphine, synergy, Antinociceptive, Writhing test, Mice

Keywords: Elaeagnus angustifolia, Morphine, synergy, Antinociceptive, Writhing test, Mice

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