fa بررسی تاثیر شغل پدر درایجاد نقص سپتوم بین دهلیزی در فرزندان بین رشته ای ( مدیریت آموزشی، تحقیقات آموزشی، آموزش پزشکی ) Interdisciplinary (Educational Management, Educational research, Statistics, Medical education عمومی General مطالعات اپیدمیولوژیک مختلف نشان داده است که برخی از مشاغل پدر با افزایش خطر ایجاد نقایص جنینی در کودکان همراه بوده است . در این ارتباط بین تماس پدر با مواد خاص و ایجاد ناهنجاری های قلبی - عروقی در کودک مورد بررسی قرار گرفته است . مطالعه به صورت مورد - شاهدی و به مدت یکسال ( از مهرماه 1378 لعایت مهرماه 1379 ) در بخش کودکان بیمارستان شهید رجائی انجام شد . کلیه بیمارانی که با تشخیص نقص سپتوم بین دهلیزی بستری شدند ، وارد مطالعه گردیدند . گروه شاهد نیز بر اساس سن و جنس مشابه انتخاب و بررسی شغل پدر در دو گروه انجام شد . <p> <strong>Background: </strong>Several epidemiologic studies indicate that some paternal occupations are associated with an increased risk of birth defects in offspring. Possible associations between paternal exposures and cardiovascular malformations were evaluated in previous studies.</p><p> <strong>Material and methods: </strong>The case-control study was performed during an academic year between October 1999 and 2000. All children with the diagnosis of atrial septal defect (ASD) were included in the study. The control group was selected through sex- and age- matched controls and paternal occupations were evaluated among both groups. The effect of exposure to special substances on</p><p> induction of ASD in children were studied.</p><p> <strong>Results: </strong>During one year, a total of 60 children (27 boys and 33 girls) aged 6 months to 16 years(mean 6.7 years) were admitted with the diagnosis of ASD at pediatric ward. Mother's age was between 15-38 years and father's age was 18-58 years. The study showed that in the case group43.3% (26 of 60) had fathers with occupations having exposed to different materials (painting colors, lead, copper, rubber, and welding material) however, in the control group only 5 patients (8.3%) had fathers with the same condition (OR = 11.9, Cl= 95%: 4.2-33.9).</p><p> <strong>Conclusion: </strong>The study showed that off springs of fathers who have been exposed to materials such aspaint, metals, rubber, etc during the six-month period prior to the maternal pregnancy are at an increased risk of ASD.</p> ،نقص سپتوم بین دهلیزی،تاثیر مواد خاص،شغل پدر Atrial septal defect, Paternal occupation, Exposure. 121 125 http://pejouhesh.sbmu.ac.ir/browse.php?a_code=A-10-1-151&slc_lang=fa&sid=1 Nakhostin Davari P, Mehralizadeh S, Noori NM پریدخت نخستین داوری 10031947532846002604 10031947532846002604 Yes سمیرا مهرعلیزاده 10031947532846002605 10031947532846002605 No نورمحمد 10031947532846002606 10031947532846002606 No