Pejouhesh dar Pezeshki (Research in Medicine)
پژوهش در پزشکی
Research in Medicine
Medical Sciences
http://pejouhesh.sbmu.ac.ir
1
journal1
1735-5311
2008-0506
fa
jalali
1401
9
1
gregorian
2022
12
1
46
4
online
1
fulltext
fa
اثر هشت هفته تمرینهای اینتروال شدید برسطوح سرمی آدیپونکتین، آیریزین و پروفایل لیپیدی زنان بیمار مبتلا به کبد چرب غیرالکلی
The Effect of Eight Weeks of Intense Interval Training on Serum Levels of Adiponectin, Irisin, and Lipid Profile in Women with Non- Alcoholic Fatty Liver Disease
تربیت بدنی و علوم ورزشی ( فیزیولوژی ورزشی - بیومکانیک ورزشی )
Physical Education and Sports Science ( Sport physiology- Sport biomecanic
پژوهشی
Original
<div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:110%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="AR-SA" style="line-height:110%"><span b="" nazanin="" style="font-family:">سابقه و هدف</span></span></b><b><span b="" lang="AR-SA" nazanin="" style="font-family:">: </span></b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"><span style="color:black">بیماری</span></span></span></span> <span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"><span style="color:black">کبدچرب</span></span></span></span> <span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"><span style="color:black">غیرالکلی</span></span></span></span> <span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"><span style="color:black">با</span></span></span></span> <span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"><span style="color:black">رسوب</span></span></span></span> <span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"><span style="color:black">چربی</span></span></span></span> <span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"><span style="color:black">در</span></span></span></span> <span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"><span style="color:black">سلول­های</span></span></span></span> <span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"><span style="color:black">کبدی</span></span></span></span> <span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"><span style="color:black">مشخص</span></span></span></span> <span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"><span style="color:black">میشود</span></span></span></span> <span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"><span style="color:black">و</span></span></span></span> <span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"><span style="color:black">درصورت</span></span></span></span> <span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"><span style="color:black">نبودکنترل</span></span></span></span> <span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"><span style="color:black">ممکن</span></span></span></span> <span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"><span style="color:black">است</span></span></span></span> <span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"><span style="color:black">سبب</span></span></span></span> <span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"><span style="color:black">فیبروز،</span></span></span></span> <span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"><span style="color:black">سیروز</span></span></span></span> <span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"><span style="color:black">و</span></span></span></span> <span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"><span style="color:black">تخریب</span></span></span></span> <span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"><span style="color:black">سلولی</span></span></span></span> <span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"><span style="color:black">کبد</span></span></span></span> <span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"><span style="color:black">شود</span></span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:">. فعالیت ورزشی یکی از عوامل کمک کننده در بهبود بیماران کبد چرب غیرالکلی است. هدف این مطالعه بررسی </span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:">اثر یک دوره تمرینهای اینتروال شدید بر مقادیر سرمی آدیپونکتین، آیریزین و پروفایل لیپیدی زنان بیمار مبتلا به کبد چرب غیرالکلی بود.</span></span></span><span lang="AR-SA" style="line-height:110%"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:110%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="AR-SA" style="line-height:110%"><span b="" nazanin="" style="font-family:">روش کار:</span></span></b> <span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:">در این مطالعه کار آزمایی بالینی تجربی تعداد 25 زن مبتلا به بیماری کبد چرب غیر الکلی با دامنه سنی 50-30 سال </span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:">براساس معیارهای ورود </span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:">به مطالعه به عنوان نمونه آماری انتخاب و به صورت تصادفی به دو گروه تمرین (13 نفر) وکنترل (12 نفر) تقسیم شدند.</span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"> تمرینهای تناوبی شدید به مدت هشت هفته (چهار جلسه در هفته و هر جلسه به مدت 48 تا 60 دقیقه) اجرا شد. نمونه­های خونی در شرایط پیش و پس آزمون برای اندازه­گیری سطوح آدیپونکتین، آیریزین و پروفایل لیپیدی گرفته شد. تحلیل آماری داده­ها با استفاده از آزمون آزمون </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times="">t</span></span></span><span style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"> مستقل و تی همبسته به وسیله نرمافزار </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times="">spss21</span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"> در سطح معناداری 0/05></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times="">p</span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"> انجام شد.</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:110%"><span style="font-family:"Times New Roman",serif"></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:110%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="AR-SA" style="line-height:110%"><span b="" nazanin="" style="font-family:">یافته</span></span></b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:110%"></span></span></b><b><span lang="AR-SA" style="line-height:110%"><span b="" nazanin="" style="font-family:">ها:</span></span></b> <span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:">نتایج </span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:">نشان داد </span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:">پس از مداخله تمرین </span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:">مقادیر سرمی</span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"> آدیپونکتین (</span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"><span style="layout-grid-mode:line">049/0</span></span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:">=</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times="">p</span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:">)، آیرزین (</span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"><span style="layout-grid-mode:line">004/0</span></span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:">=</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times="">p</span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:">) و </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times="">HDL</span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"> (</span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"><span style="layout-grid-mode:line">005/0</span></span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:">=</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times="">p</span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:">) افزایش معنادار و مقادیر </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times="">LDL</span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"> (</span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"><span style="layout-grid-mode:line">0/001</span></span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:">=</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times="">p</span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:">)، </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times=""> TG</span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:">(</span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"><span style="layout-grid-mode:line">0/001</span></span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:">=</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times="">p</span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:">)، </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times="">TC</span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"> (</span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:"><span style="layout-grid-mode:line">0/001</span></span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:">=</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times="">p</span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:">) کاهش معناداری در گروه تمرین در مقایسه با گروه کنترل داشتند </span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:">(0/05</span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times="">≥</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times="">p</span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:">).</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:110%"><span style="font-family:"Times New Roman",serif"></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:110%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="AR-SA" style="line-height:110%"><span b="" nazanin="" style="font-family:">نتیجه</span></span></b><b><span dir="LTR" style="font-size:10.0pt"><span style="line-height:110%"></span></span></b><b><span lang="AR-SA" style="line-height:110%"><span b="" nazanin="" style="font-family:">گیری</span></span></b><span lang="AR-SA" style="line-height:110%"><span b="" nazanin="" style="font-family:">:</span></span> <span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:">به نظر می­رسد<b> </b>با توجه به اثرات مثبت تمرینهای اینتروال شدید برسطوح سرمی آیرزین، آدیپونکتین و پروفایل لیپیدی در بیماران </span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:110%"><span b="" nazanin="" style="font-family:">مبتلا به کبد چرب غیرالکلی، به نظر میرسد میتوان این تمرینها را به عنوان یک شیوه درمانی غیردارویی برای بهبود این بیماران توصیه کرد.</span></span></span><span lang="AR-SA" style="line-height:110%"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span><br>
</div>
<div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:110%"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:10.0pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times="">Background and Aim:</span></span></span></b> <span style="font-size:10.0pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times="">Non- alcoholic fatty liver disease is characterized by fat deposition in liver cells and, if not controlled, may cause fibrosis, cirrhosis, and cell destruction of the liver. Sports activity is one of the contributing factors in the recovery of non-alcoholic fatty liver patients. The aim of this study was to investigate the effect of eight weeks of high- intensity interval training (HIIT) on serum levels of adiponectin, irisin, and lipid profile in women with non- alcoholic fatty liver disease.<span style="background:white"></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:110%"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:10.0pt"><span style="background:white"><span style="line-height:110%"><span new="" roman="" style="font-family:" times="">Methods:</span></span></span></span></b> <span style="font-size:10.0pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times="">In this experimental clinical trial, 25 women with non-alcoholic fatty liver disease with an age range of 30-50 years were selected as a statistical sample based on the inclusion criteria and randomly divided into two exercise groups (13 people) and control groups (12 people). Intense interval training was performed for 8 weeks (four sessions per week and each session lasting 48 to 60 minutes). Blood samples were taken before and after the test to measure the levels of adiponectin, irisin, and lipid profile. Statistical analysis of the data was done using independent t-</span></span></span> <span style="font-size:10.0pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times="">test and correlated t-</span></span></span> <span style="font-size:10.0pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times="">test using spss21 software at a significance level of p<0.05.<span style="background:white"></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:110%"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:10.0pt"><span style="background:white"><span style="line-height:110%"><span new="" roman="" style="font-family:" times="">Results:</span></span></span></span></b> <span style="font-size:10.0pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times="">The results showed that after training intervention, the serum levels of adiponectin (p= 0.049), irisin (p= 0.004), and HDL (p= 0.005) significantly increased, and LDL (p= 0.001), TG (p= 0.001), TC (p= 0.001) had a significant decrease in the exercise group compared to the control group (p≥0.05).<span style="background:white"></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:110%"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:10.0pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></span></b> <span style="font-size:10.0pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times="">Considering the positive effects of HIIT on serum levels of irisin, adiponectin, and lipid profile in patients with non- alcoholic fatty liver, it seems that these exercises can be recommended as a non- pharmacological treatment to improve these patients.</span></span></span><span style="font-size:10.0pt"><span style="line-height:110%"><span style="font-family:"Times New Roman",serif"></span></span></span></span></span></span><br>
</div>
کبد چرب غیرالکلی؛ آدیپونکتین؛ آیریزین؛ پروفایل لیپیدی؛ تمرینهای اینتروال شدید
Fatty liver, Adiponectin, Irisin, Lipid Profile, High Intense Interval Training
38
48
http://pejouhesh.sbmu.ac.ir/browse.php?a_code=A-10-3965-5&slc_lang=fa&sid=1
Bahloul
Ghorbanian
بهلول
قربانیان
b.gorbanian@gmail.com
100319475328460027927
100319475328460027927
Yes
Department of Sports Sciences, Faculty of Educational Sciences and Psychology, Azerbaijan Shahid Madani University, Tabriz, Iran.
گروه علوم ورزشی، دانشکده علوم تربیتی و روانشناسی، دانشگاه شهید مدنی آذربایجان، تبریز، ایران.
Safa
Eghtesadi
صفا
اقتصادی
100319475328460027928
100319475328460027928
No
Department of Sports Sciences, Faculty of Educational Sciences and Psychology, Azerbaijan Shahid Madani University, Tabriz, Iran.
گروه علوم ورزشی، دانشکده علوم تربیتی و روانشناسی، دانشگاه شهید مدنی آذربایجان، تبریز، ایران.