Volume 36, Number 3 (11-2012)                   Research in Medicine 2012, 36(3): 151-156 | Back to browse issues page


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Motovali-Bashi M, Bordbar M, Rezaei H. Study of association between T/C single nucleotide polymorphism in CYP1A1 gene and cancer initiation and smoking status in lung cancer patients. Research in Medicine. 2012; 36 (3) :151-156
URL: http://pejouhesh.sbmu.ac.ir/article-1-1081-en.html

Genetic division, Biology department, Faculty of Sciences, University of Isfahan, Isfahan, Iran , mbashi@sci.ui.ac.ir
Abstract:   (4550 Views)
Abstract Background: Several single nucleotide polymorphisms have been found in CYP1A1 gene and it was reported that C allele in T/C gene polymorphism is associated with lung cancer. Current study investigates interaction between cigarette factor and C/T polymorphism in the m1 locus. Methods: Present study is a case-control and retrospective study. T/C polymorphism in 112 patients with lung cancer and 120 healthy controls was genotyped using RFLP-PCR technique. Association of the polymorphism and initiation of cancer including cigarette risk factor was analyzed statistically. Results:, Association was seen between patient and control groups in the distribution of gene polymorphism (P<0.0001). No significant difference was seen in distribution of gene polymorphism between the two patient groups (smokers and non-smokers) (P=0.098). Conclusion: Results of present study show individuals with C allele are susceptible to lung cancer independent of cigarette smoking factor in Isfahan population. However determining the role of C allele as a biological risk factor needs more investigation. Keywords: Lung cancer, CYP1A1, Single nucleotide polymorphism, Cigarette.
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Type of Study: Original | Subject: Cellular and Molecular
Received: 2013/02/2

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