Abstract Background: In recent years, many authors considered the effects of honey in treatment of different types of wounds. Pressure ulcers are one of the most important health problems with a challenging treatment. In current study, we evaluated the effects of an ointment containing honey, sesame and camphor in treating pressure ulcers in diabetic patients. Materials and methods: In current randomized clinical trial, 60 patients assigned to two groups randomly. Daily irrigation using normal saline and dressing with sterile gauze was performed. In control group, placebo and in case group, the ointment containing honey, sesame and camphor (Kimia ointment) was used twice a day for 8 weeks locally. Before and after the treatment, PUSH tool 3.0 was completed. Also, the rate of infection requiring surgical debridement was compared between groups. Mann-Withney U, Wilcoxon and chi-square tests were used. Results: Two groups were the same in terms of sex and age. There were one and 5 patients required surgical debridement in case and control groups, respectively (p=0.195). The PUSH score decreased significantly in two groups after the treatment (p<0.001). Before the treatment, the PUSH scores were the same. At the last visit, the PUSH score in ointment and placebo group was 4.9±1 and 6.8±1.2, respectively (p<0.001). Conclusion: Treating pressure ulcers in diabetic patients applying ointment-containing honey, sesame and camphor can be helpful in accelerating the healing process. However, more extensive studies are needed.