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Shahid Beheshti Medical University , elahe.abooali@gmail.com
Abstract:   (283 Views)
Background and Aim: Helicobacter pylori infection is known as an important risk factor in development of ulcer, gastritis, and malignancy. However, recently the systemic effect of H. pylori infection on other organs such as infection of liver and development of non-alcoholic fatty liver disease has been found. The prevalence of HPI in NAFLD patients has been noted, as the prevalence of NAFLD is growing worldwide. The aim of this research is to determine the prevalence of h. pylori in NAFLD patients. Then, in case of positive relationship, through the easy and inexpensive control and treatment of H. pylori, it is possible to prevent development of NAFLD whose prevalence is increasing.
Materials and methods: This research is descriptive-cross sectional, in which NAFLD patients referring to digestion clinic of Loghman Hakin hospital were chosen through available sampling. After confirmation of NAFLD through ultrasound, serology test of H. pylori antibody (IgG) was requested. Then, the collected data were coded and introduced into computer. The quantitative data have been described by mean and standard deviation, while the qualitative data have been described through frequency and percentage. Chi-do and independent t-test have been used for data analysis. The prevalence was determined by confidence interval 95%, and the statistical tests were performed at significance level of 5%.
Results: In this study, 181 NAFLD patients were tested. The mean age of the patients was 44.15±11.95 years. Further, 70 (38.7%) and 111 (61.3%) were male and female, respectively. One patient (0.55%) of the NAFLD group was Grade IV, 15 (8.29%) were grade III, 51 (28.18%) Grade II, and most patients (114, 63%) Grade I. H. pylori was positive among 114 patients (63%). The prevalence of positive IgG test among women and men was 64% and 61.4%, respectively. No significant difference was observed in IgG test prevalence between men and women (p=0.731). No significance difference existed either between the age of patients in terms of IgG test results (p=0.441). Although the prevalence of H. pylori was less in non-smokers, no significance difference was observed in the prevalence of H. pylori in terms of smoking status. Finally, no significant difference was observed between the two groups in terms of BMI (p=0.437).
Conclusion: This study indicated that the prevalence of H. pylori is relatively high in NAFLD patients. This high prevalence can be a cause for the possible relationship between H. pylori and NAFLD. 
Type of Study: Original | Subject: Internal medicine: (glands, lungs, digestion, kidneys, blood, rheumatology,Geriatrics )
Received: 2019/06/16 | Accepted: 2019/07/31

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