Volume 44, Issue 2 (6-2020)                   Research in Medicine 2020, 44(2): 366-373 | Back to browse issues page

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Raheb J, Ahmadianpour V, mowla J, sotoodeh nejad nematolahi F. Possible to use gold nanoparticles for diagnosing the early diagnosis of prostate cancer.. Research in Medicine. 2020; 44 (2) :366-373
URL: http://pejouhesh.sbmu.ac.ir/article-1-2086-en.html
National Institute of Geneticas and biotechnology , jam@nigeb.ac.ir
Abstract:   (2202 Views)
background and purpose: studies that have been tested on the blood of prostate cancer patients by using DLS method and examining the changes of protein size, but this method has not been investigated so far, but this method is intended to determine the prostate cancer among Iranian patients by using gold nanoparticles.
Materials and Methods: In this study, descriptive method was used. Serum of 60 Iranian men aged between 40 and 90, consisting of 20 healthy samples, 20 samples with hyperplasia and 20 samples with prostate cancer. Optical scattering changes were measured by DLS of the surface of gold nanoparticle blended with these tubes, and the responses were compared with the PSA index. test results are performed using the t - test and anova tests
Findings: based on the results of this study , there was no significant difference between the two groups ( p > 0.05 ) . the relationship between the amount of light scattering and serum level of psa was not found .
Conclusion: It seems that performing this test requires advanced equipment to keep the temperature constant as well as DLS limitations for the diagnosis of prostate cancer. This test may not be a simple and accurate method for early detection of this cancer and it is suggested that other methods be used to diagnose it
 
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Type of Study: Original | Subject: Biochemistry
Received: 2019/08/18 | Accepted: 2019/10/16 | Published: 2020/06/20

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