Volume 44, Issue 2 (6-2020)                   Research in Medicine 2020, 44(2): 366-373 | Back to browse issues page

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Raheb J, Ahmadianpour V, mowla J, sotoodeh nejad nematolahi F. Possible to use gold nanoparticles for diagnosing the early diagnosis of prostate cancer.. Research in Medicine 2020; 44 (2) :366-373
URL: http://pejouhesh.sbmu.ac.ir/article-1-2086-en.html
National Institute of Geneticas and biotechnology , jam@nigeb.ac.ir
Abstract:   (2464 Views)

Background:studies Studies that have been testedinvestigated on the blood of prostate cancer patients by using DLS method and examining the changes of protein size have shown the sensitivity of the method, but so far, this method has not been investigated in Iran so far; therefore, the present study was conducted , but this method is intended to determine the prostate cancer among Iranian patients by using gold nanoparticles.
Materials and Methods: In this the present study, descriptive study, method was used. Sserum samples were obtained fromof 60 Iranian men aged between 40 and 90, consisting includingof 20 healthy samples, 20 samples with hyperplasia, and 20 samples with prostate cancer. Optical scattering changes were measured by using DLS of the surface of gold nanoparticle blended with these tubes, and the responses were compared with the PSA index. testThe results are were analyzed performed using theusing t - test and anova ANOVAtests.
Findings: based Based on the results of this the present study , there was is no significant difference between the two groups ( p > 0.05 ) and. the no relationship was found between the amount of light scattering and serum level of psa was not found .

Conclusion: It seems that performing this test requires advanced equipment to keep the temperature constant as well as DLS limitations for the diagnosis of prostate cancer. This test may not be a simple and accurate method for early detection of this cancer and it is suggested that other methods be used to diagnose it.

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Type of Study: Original | Subject: Biochemistry
Received: 2019/08/18 | Accepted: 2019/10/16 | Published: 2020/06/20

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