Volume 47, Issue 1 (4-2023)                   Research in Medicine 2023, 47(1): 53-61 | Back to browse issues page

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Mokhberi G, Malekzade Moghani M, Rakhshan A, Sajjadi Rad M. Investigating the Association between Tumor- Infiltrating Lymphocytes and Complete Pathological Response in Breast Cancer Patients after Neoadjuvant Chemotherapy. Research in Medicine 2023; 47 (1) :53-61
URL: http://pejouhesh.sbmu.ac.ir/article-1-2953-en.html
Department of Radiotherapy, School of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran. , gzlmkh@gmail.com
Abstract:   (420 Views)
Background and Aim: Breast cancer is the most common type of cancer in women, in iran. Hence, determination of the optimal treatment and contributing factors are important. The main aim of the current study was to determine the association between tumor- infiltration lymphocytes (TIL) and complete pathological response in breast cancer patients after neoadjuvant chemotherapy.
Methods: In this comparative retrospective study, 73 consecutive patients with breast cancer who underwent core needle biopsy and then neoadjuvant chemotherapy in Shohada Tajrish hospital, Tehran, Iran, from 2011 to 2019 were enrolled. Then, the association between TIL and complete pathological response in patients was determined.
Results: The results in this study demonstrated that 13.3% and 35.7% of those with TIL less than 10 and more than 10, respectively had a complete pathological response that showed a statistically significant difference (P = 0.025).
Conclusion: Tumor Infiltration of lymphocytes and complete pathological response in breast cancer patients who underwent neoadjuvant chemotherapy are interrelated, and TIL may be used to predict the response.
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Type of Study: General | Subject: Radioterapy
Received: 2020/09/22 | Accepted: 2022/11/15 | Published: 2023/01/29

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