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Faculty of Veterinary Medicine, Azad University, Tabriz Branch , hosein.taghilou3972@gmail.com
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Background and purpose :Non-alcoholic fatty liver disease is a condition in which triglycerides accumulate in liver cells of people who do not have a history of alcohol use or use alcohol at a low rate.The aim of this study was to investigate the effect of alcoholic extracts of St. Johnchr('39')s wort and borage plants individually and in combination on non-alcoholic fatty liver in Wistar rats. Due to their innovation and high antioxidant, these two plants were selected.
Materials and MethodsIn this experimental laboratory intervention study, 70 male Wistar rats were randomly divided into 7 groups of 10, randomly assigned to 10 mice as the negative control group. And the rest of the rats are treated with a high-fat diet. Twenty-one days after the onset of a high fat diet and fatty liver, they began to be treated with an alcoholic extract of Silybum marianum and Eryngium and kept for 2 months individually and combined in two doses of at least 200 and a maximum of 400 mg in kg. And at the end of the treatment period in 1398 to evaluate the level of concentrations of unsaturated fatty acids (NEFA), non-esterified fatty acids (BHB: hydroxybutyrate-Beta), alanine aminotransferase (ALT), aspartate amino trans (AST) Aspartate aminotransferase, gamma glutamyl transferase (GGT) blood samples were taken and the data were analyzed. The results of the study were used for analysis using SPSS software version 24.The results were compared using one-way analysis of variance statistical test at 95% probability level and significance level of 0.05.
Findings: The results showed that NEFA, BHBA, ALT, AST and GGT levels in the treated groups of alcoholic extract of Silybum marianum and Eryngium combination and single effect on fatty liver were more than control group and positive control group. (P <0.05) The amount of AST in the control and positive groups (145.4 ± 9.1) and in the negative (114 ± 11.4) and combined control (136.1 ± 2.9) are these values.                                  
Conclusion: It seems that thistle and buckthorn can be used to treat non-alcoholic fatty liver disease, which of course requires clinical trials in livestock, which improves the amount of liver enzymes due to the effect of these plants on liver tissue and Improving the amount of related enzymes. Therefore, these plants can be used in future research on livestock and their effects on improving liver enzymes and protecting liver tissue.
Type of Study: Original | Subject: veterinary
Received: 2020/12/8 | Accepted: 2022/02/8

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