Staphylococcus aureus-induced septic polyarthritis is a rare entity characterized by the involvement of multiple joints. IV drug abusers are at increased risk, and it could be fatal if prompt intervention is delayed. Case report: A 30–year old male addict, (IV drug abuser), was admitted in Loghman hospital with high fever (38.5ºC), pulmonary symptoms, (cough and suppurative sputum), and pain and swelling in knees, ankles and both wrist joints. Blood and synovial fluid cultures were taken and the diagnosis of staphylococcus aureus-induced septic polyarthritis was confirmed. He was treated with vancomycin, penicillin and cephazolin. Although septic polyarthritis is a rare life-threatening condition, it should be kept in mind in immunocompromised subjects and IV drug abusers. Complete recovery is feasible with prompt diagnosis and intervention. KEYWORDS: Septic polyarthritis, Staphylococcus aureus.

Keywords: KEYWORDS: Septic polyarthritis, Staphylococcus aureus.

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