F1 Ghotbi, M2 Tghiloo, Gashb A2,
Volume 33, Issue 1 (5-2009)
Abstract
Abstract:
Background: Hyperbilirubinemia is a common problem in newborn infants and may progress to kernicterus if not treated. The objective of this study was to determine the therapeutic effect of clofibrate in full-term healthy neonates with non-hemolytic hyperbilirubinemia.
Material and method: A randomized clinical trial was performed on two groups of healthy full-term neonates with jaundice. Clofibrate group, (n=50), received a single dose of oral clofibrate (100mg/kg), plus phototherapy, while the control group (n=50), received only phototherapy.
Results: The mean plasma total bilirubin levels at 12, 24, and 48 hours after treatment were significantly lower in the clofibrate treated group, as compared with the control group (p=0.001).
At 48 hours of treatment, 48% of patients in the clofibrate group, had bilirubin levels <12 mg/dl in comparison with 16% of control group (p=0.001).
Treatment with clofibrate also resulted in a shorter duration of hospital stay as compared to the control group (p=0.001).
Conclusion: A single oral dose of clofibrate (100mg/kg), along with phototherapy is more effective than phototherapy alone in treatment of non-hemolytic hyperbilirubinemia in full-term healthy newborn infants.
KEYWORDS: Neonatal jaundice, Clofibrate, Non-hemolytic hyperbillirubinemia, RCT.
