Showing 24 results for Malek
Fereydon Azizi, Hamid Reza Farshchi Nasr, Hossein Malek Afzali, Jamileh Rahiminia, Bijhan Mahdavi,
Volume 23, Issue 4 (Winter 1999)
Abstract
Considering conflicting reports on the success efficacy of health services, this study was carried out to determine the sty le of utilization of health and treatment services in health centers of rural areas in 1996.
The descriptive and cross-sectional strategy of this research study was performed in health centers of 11 provinces and their villages were classified into high, intermediate, and low groups according to the quality of presented services. For this purpose, six physicians were involved with the project using similar questionnaires and methods of evaluation. In this regard, every one of them studied one or two provinces for a period of 1-3 months. They referred to 196 villages and had interview with 1064 families, 62 health assistants, and 27 physicians and completed the questionnaires.
It was found out that the first place of refer for the villagers was rural health centers and then in order of impo11ance were doctor's office and health and tremment centers. In well-conditioned regions, the villagers rarely referred to rural health and treatment centers (6%) and the greatest reference was the office of physicians (34%). In this regard, most of them expressed the closeness of health center as the major cause of refer. The existence of free services especially drng, having trust to health assistants, and observance of referral system were the other causes ofrefer. On the basis of their views, the availability of the necessary drugs was 45.5%, 76.6% and 57.2% in poor, moderate and well-conditioned regions respectively. The suggestions of health assistants for the improvement of health service presentation in order of frequency were the availability of the approved drugs, holding courses of training and re-education, establishing the rural health and treatment centers in line with the existing health centers and continuous or intermittent presence of physicians in rural areas. According to the views of physicians in less than half of the cases, there is enough supply of the necessary drugs and in 74.1 % of cases, the existence of the necessary equipments has satisfied the physicians. Meanwhile, in none of the studied villages, there did not exist all of the 41 approved drugs completely, but the contraceptive pill existed in 96.5% of cases. Furthermore, considering the list of necessary equipments, the necessary items did not exist in many of the cases.
Malek Khosravi Sh , Kaboudi B ,
Volume 27, Issue 4 (12-2003)
Abstract
Background : Prior studies have shown an association between preeclampsia and increased levels of plasma insulin. The present study was conducted to compare the changes in fasting plasma insulin levels in pre-eclamptic women with normal controls during pregnancy.
Materials and methods : In a nested case-control study, 674 parturients, with normal blood pressure in the 20th gestational week, were followed through the second and third trimesters. Blood samples were obtained from 16 healthy and 16 preeclamptic women during the second and third trimesters to compare their insulin and glucose levels. Groups were matched according to age, parity, gestational age, and body mass index.
Results : The fasting insulin levels increased from 15.3±1.3μIu/ml to 25.3±1.4, between 2nd and 3rd trimesters in pre-eclamptic women (p<0.01) and from 10.4±0.9 to 16.2±1.3 μIu/ml in the control group (p<0.01). Fasting insulin level and its mean changes during the course of pregnancy were higher in preeclamptic women as compared to controls (p<0.01), whereas, there was no significant change in glucose levels during pregnancy in either group.
Conclusion : Women who develop preeclampsia have higher insulin levels before the clinical evidence of disease than women who remain normotensive during pregnancy and this may increase further during the disease course. These changes may be in association with insulin resistance in Na transport mechanism of cell membrane.
, , , , , , Hajinasrollah E, Salehi N, Khshkar A, Malekpour, Ghaseminejad A, Valaie N, Hojati M: ,
Volume 29, Issue 3 (9-2005)
Abstract
Background: The incidence of complications of laparoscopic cholecystectomy has increased dramatically since the introduction and widespread use of laparoscopic cholecystectomy in 1990. Bile duct injuries are among the most important complications of this approach.
Methods : From January 1998 to January 2002, a total of 155 laparoscopic cholecystectomy were performed at the Loghman Medical Center . A retrospective analysis of bile duct-related complications was carried out.
Results : There were 6(4.4%) major complications including major bile duct injury, cystic duct leak, bile duct strictures, and hemorrhage that required laparotomy at later stage.
Conclusion : Results revealed that laparoscopic cholecystectomy is an operation associated with low morbidity and mortality rate, but bile duct injury is still a major concern. We believe that clear demonstration of anatomy is the cornerstone of safe, successful laparoscopic cholecystectomy.
, , Salehian Mt , Malek M, Azizi F ,
Volume 29, Issue 3 (9-2005)
Abstract
Thyroid hemiagenesis with or without isthmus is a rare congenital disorder. Papillary thyroid carcinoma associate with hemiagenesis is very rare. A 42 years old female with chief complain of cervical mass was referred to our center. In physical examination, she had a 1.5 × 1.5 nodule in right lobe of thyroid. The result of thyroid nodule fine needle aspiration was reported papillary thyroid carcinoma. The right thyroid lobe was resected but there was not any trace of thyroid in left side and isthmus on trachea. In thyroid scan that was achieved one month later, iodine absorption was observed only in right thyroid bed. As a result the left lobe thyroid hemiagenesis and isthmus were approved. The final pathology report was thyroid papillary carcinoma. It was a rare case of thyroid hemiagenesis associate with thyroid papillary carcinoma that usually diagnosed accidentally.
, Malekpour Afshar R, Hayatbakhsh Abbasi M ,
Volume 30, Issue 1 (3-2006)
Abstract
Background: Human behavior is influenced by what we know or believe. In research projects, when the researcher expected a particular finding then explaining the results would be biased. Thus, blinding is a fundamental aspect of all research projects.
Materials and methods: A retrospective descriptive study was performed. During a 4-year period (2001-2004) all approved research projects in deputy of research affaires of Kerman University of Medical Sciences that had been referred to pathology laboratories were evaluated. The mechanism used for blinding is questioned by interview with researchers or reviewing the proposals.
Results: Only 31% of research proposals had observed blinding policies correctly. Mistakes occurred most often in blinding process were as follow: single pathologist who was aware of research design, inappropriate group labeling by alphabetic abbreviations rather than case labeling by randomized numbers, remaining of interventions such as orthopedic devices in the test group, step by step remittance of specimens to pathology laboratory in multiphase studies, etc.
Conclusion: Our results revealed that the pathologist should be blinded to group assignment. The blinding process and evaluating techniques should be supervised by statisticians and the monitoring committee (research center).
, , Rahmati Roodsari M, Malekzad F, Ebrahimzadeh Ardakani M ,
Volume 30, Issue 2 (6-2006)
Abstract
.: Department of Dermatology and Skin Research Center, Shaheed Beheshti University of Medical Sciences , Tehran , Iran
Abstract:
Background: Prisoners are susceptible to dermatological diseases due to their communal life in prison, high-risk behaviours and being under stress. The aim of our project was to investigate the prevalence of dermatological diseases in an Iranian prison.
Materials and methods: In this observational-cross sectional study 1404 prisoners were randomly selected and examined by two dermatologists.
Results: All the examinees were male prisoners. Their average age was 34 +/- 11.2 and average time of imprisonment was 1.9+/- 2.8 years. 7% of cases (97) complained of generalized itching and 10% (140) had a localized itching. Tattoos were seen on the body of 261 prisoners (19%). 783 person (56%) (CI 95%: 53-59%) had a dermatological disorder and 621 (44%) were totally healthy. Truncal Acne Vulgaris was the most common disorder that was seen in 184 cases (13%). 158 cases (11.2%) had Tinea Versicolor. Other diseases were Facial Acne Vulgaris in 78 cases (5.5%), Dry Skin in 75 cases (5.3%) and Hand Eczema in 55 cases (4%). The average age of patients with Facial and Truncal Acne was lower. However, Acne was seen more in the patients with history of addiction. Scabies was more prevalent in crowded rooms.
Conclusions: The most prevalent skin diseases were truncal Acne and tinea versicolor our finding revealed that scabies prevalence is meaningfully related to duration of imprisonment. It is recommended that all the prisoners should be examined before entering the prison and also periodically during their imprisonment in order to receive suitable treatment and decrease the risk of transmitting contagious diseases in prison.
Dr M Rahmati Roodsari, Dr F Malekzad, Dr R Amini, Dr M Shiri,
Volume 30, Issue 3 (9-2006)
Abstract
Background: Skin disorders especially infectious and contagious diseases are quite common in crowded environment. Few epidemiological studies have been conducted among university students, thus the present study was carried out to determine the frequency of skin disorders among university students in Shahid Beheshti University of Medical Sciences' dormitories.
Materials and methods: Totally, 1279 students were selected for this cross sectional study. They were examined by two dermatologists during a 3-month period. T-test and chi square were used for data analysis.
Results: Of 1279 students, 1173 (91.7%) had skin disorder, of whom 658 (56%) were male and 515 (44%) were female. Acne (56%), hair loss among females (14%), seborouic dermatitis (9%), freckle (10%), hand eczema (10%), pityriasis versicolor (8%), xirosis (6%) and eczema (5%) were the most common skin disorders. There was an inverse strong relationship between acne and age.
Conclusions: Skin disorders are quite common among university students.
Mt Salehian, M Mehrdad, M Moghimi, M Hosseinzadeh Malek,
Volume 30, Issue 4 (12-2006)
Abstract
Primary hyperparathyroidism is a quite frequent disorder however, giant parathyroid adenoma is a rare entity. We described a 39-year old woman presenting with lower extremities bone pain within the recent 3 years. She had been receiving levothyroxin during the past 10 years due to hypothyroidism, meanwhile, she had a bulge right thyroid lobe. Laboratory examinations revealed she was euthyroid, however, scanning showed parathyroid adenoma. During surgery, an adenoma measured 2×3×6cm, weighted 22gr was resected. Giant parathyroid adenoma present with non-characteristic symptoms, thus, routine laboratory measurements including serum calcium and phosphorous should be proposed for suspected individuals.
.
Mh Larizadeh, R Malekpour-Afshar,
Volume 31, Issue 1 (spring 2007)
Abstract
Background: Ethical issues arise in oncology more frequently than before. Informing patient of his/her disease status and prognosis is of utmost importance. The present study was designed to assess knowledge of patients with cancer towards their disease status in Kerman.
Materials and methods: For this study, 150 patients with cancer referring to the radiotherapy-oncology ward of Shafa hospital in Kerman were interviewed. We attempted to find out the following issues: Patients’ knowledge towards their diagnosis, prognosis, etiology, duration and probable side effects of treatment. Then, the association between patients’ knowledge and studied factors was determined.
Results: Of 150 patients, 53 (35.3%) were completely informed of their disease while 11 patients (7.3%) were aware of the prognosis. Totally, 63(42%), 16(10.7%) and 106(70.7%) of patients were aware of the disease complications, etiology and the treatment duration, respectively. 58 patients (38.7%) were involved in decision making about their treatment protocol. Patients’ knowledge was associated with level of education, place and type of treatment (p<0.05).
Conclusion: Iranian patients with cancer were not sufficiently informed of their disease status.
M Rahmati Roodsari, F Malekzad, R Shobeiri,
Volume 31, Issue 2 (9-2007)
Abstract
Background: Dermatologic diseases are common in patient with chronic renal failure, (CRF), being managed with hemodialysis. This study was done to determine the different patterns of skin involvement in these patients.
Materials and methods: We examined 215 patients on hemodialysis in four hemodialysis centers in Tehran in 2006.
Results: Of 215 patients, (122 men and 93 women), with the mean age of 56.4±16.2 years (range, 17 to 86 years), 202 (94%) had at least one type of dermatologic disease. They had been on dialysis from at least 1 year to 27 years. The most common dermatologic disease was xerosis, (59.1%). There was a significant relation between the patients’ age and solar elastosis (P=0.01), splinter hemorrhage (P=0.018), and longitudinal ridging (P=0.01). Also, the relationship between the duration of hemodialysis and yellow discoloration, xerosis, and koilonychia were statistically significant, (P=0.047, 0.019, and 0.01, respectively). A significant association was found between the patients’ job and folicullitis (p= 0.01), and between the underlying disease resulting in CRF and folliculitis or furunculosis (P= 0.039).
Conclusion: As dermatologic diseases are very common in patients with chronic renal failure, referral to a dermatologist for optimal management will improve the quality of life in these patients.
Fallah F, Karimi A, Eslimi G, Rafie Tabatabaie S, Goudarzi H, Radmanesh Ahsani R, Malekan M, Navidinia M, Ghabel Rahmat F, Moradi A,
Volume 32, Issue 2 (Summer 2008 2008)
Abstract
Background: One of the most important problems for street children is the health issue. Many of these children are suffering from malnutrition, anemia, and respiratory, gastrointestinal and dermatologic disorders and also acquired infections such as hepatitis, AIDS, and tuberculosis. According to the emphasis for performing vaccination of high risk children, recognition of these groups has especial importance.
Materials and methods: In this descriptive study 203 street children were gathered from different places of Tehran and settled at a welfare center. These children were clinically examined by a pediatrician and requested to answer a questionnaire. Blood samples (3CC) were obtained from each of them in order to determine the existence of Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) infections by ELISA method.
Results: Among 203 street children studied in this research, 196 were boys and 7 were girls. Six cases (3%) were HBsAg positive, 54 cases were HBsAb positive (26.6%) and 16 cases were HBcAb positive (8%). Seven cases (3.5%) were HCVAb positive. All of the positive cases were boys.
Conclusion: According to these positive results for hepatitis B and C, additional laboratory examination for screening of acquired infectious disease such as Hepatitis seems to be necessary.
Mohammad Reza Maleki, Azadeh Fatehpanah2, Mahmood Reza Gohari,
Volume 34, Issue 1 (3-2010)
Abstract
Abstract
Background: The Baldrige Criteria for Performance Excellence provide a systems perspective for understanding performance management. They reflect management practices against which an organization can measure itself. The Criteria have been accepted internationally as the model for performance excellence.
Methods: This descriptive cross-sectional study was performed at Hasheminejad hospital, a training hospital of Iran University of Medical Science And Health Services, in Tehran. Members of the study team interviewed the Hospital administrator and senior managers according to the standard global Malcolm Baldrige questionnaire and documented the data. 7 criteria were used for performance assessment.
Results: This hospital got 426 points from a maximum of 1000 (42.6%). Of 426 point, 46 (37% of maximum point) was for leadership criteria, 38 (44%) for strategic planning, 41 (50%) for focus on patients and other costumers, 40 (44%) for criteria of data assessment, analysis and management, 43 (51%) for focus on personnel, 33 (39%) for process management and 185 (41%) for function of organization.
Conclusion: Baldrige model can be used as comprehensive model for assessing the performance of training hospitals. By using this model, managers can find strengths and weaknesses of organizations and then use this model for performance improvement.
Keywords: performance assessment, Malcolm Baldrige, training hospital. Hasheminejad, Excellence model.
Samera Salimpour Abkenar, Reza Mohammad Ali Malek, Soodabeh Taher,
Volume 36, Issue 1 (6-2012)
Abstract
Abstract
Background: Cotton fabric which is widely used in hospital clothing and healthcare textiles, is known to be susceptible to microbial contamination. It is logical to think that the poly (propylene imine) (PPI) dendrimers (through their inherent cationic nature) with a large number of terminal primary amino groups, may have antimicrobial activity. This study was conducted to investigate the effect of PPI dendrimer on the antimicrobial property of cotton fabric.
Methods: This experimental study was done on two generations of the PPI dendrimers (G2- and G5-PPI-NH2) which were grafted on cotton fabric using cross linking agents (Citric and Glutaric acids). Antimicrobial activity of 1 control (untreated sample) and 2 experimental (treated and grafted samples with the PPI dendrimers) groups was evaluated by zone of inhibition method against three types of bacteria (Staphylococcus aureus, Pseudomona aeruginosa and Escherichia coli) and a fungus (Candida albicans) according to the PN-EN ISO 20645:2007 standard (before and after 5 washing cycles).
Results: In the control group, (untreated sample), the microorganisms grew underneath and around edges of the sample. In the second experimental group (treated samples with PPI dendrimers) the microorganisms did not grow underneath and around edges of the sample, but zone of inhibition of the samples was decreased after 5 washing cycles. In third experimental group (grafted samples with PPI dendrimers) the microorganisms did not grow underneath the grafted samples even after 5 washing cycles.
Conclusion: It seems that the grafted cotton fabric with the PPI dendrimers has excellent antimicrobial property against the applied microorganisms even after repeated washing cycles.
KEYWORDS: Poly (propylene imine) dendrimer, Antimicrobial property, Staphylococcus aureus, Pseudomonades aeruginosa, Escherichia coli, Candida albicans.
Salar Bakhtiar, Azar Babakhani, Mohammad Hossein Maleki, Motahhareh Zaherara, Elham Davoodian, Kourosh Sayeh Miri, Seyed Abdolreza Mortazavi Tabatabaei,
Volume 36, Issue 5 (2-2013)
Abstract
Abstract
Background: PGC-1α is involved in the regulation of several metabolic processes and its reduced expression has been observed in early stages of type 2 diabetes, (T2D). Changes in activity of PGC-1α, probably due to its polymorphisms, have extensive effects on metabolic processes in people with T2D. The association of rs2970847 polymorphism of PGC-1α gene with T2D has been investigated in several studies, but the results of these studies are diverse and sometimes contradictory. The aim of this meta-analysis was to investigate the relationship between Thr394Thr polymorphism of PGC-1α gene and T2D.
Materials and Methods: This study was a systematic review of the available literature and resources. To find related documents, the following literature databases were searched: Scopus, PubMed, Google scholar, SID, Irandoc and Magiran. Articles were searched by combining critical and sensitive keywords, including: rs2970847, Thr394Thr polymorphism, PPARGC1A, PGC-1, PGC1alpha, Type 2 diabetes, type 2 diabetes, and T2D.
Results: In 7 reviewed papers, the total number of T2D and control subjects was 2146 and 2814, respectively. For the GG, GA, and AA genotypes of the Thr394Thr polymorphism, OR (95% CI) were equal to 0.59 (95% CI=0.52-0.67), 1.25 (1.10-1.43), and 1.75 (1.45-2.08), respectively. The results showed that the association between the GG and GA genotypes of Thr394Thr polymorphism and susceptibility to T2D was statistically significant (P <0.05).
Conclusion: This study generally demonstrated that rs2970847 polymorphism of PGC-1α gene is significantly associated with the risk of T2D.
Keywords: PGC-1α, T2D, Thr394Thr polymorphism, rs2970847, Meta-analysis.
Tahermajid Roshandel Arbatani, Shahriar Janbazi, Majid Malek Pour,
Volume 37, Issue 3 (11-2013)
Abstract
Abstract Background: Transcendental leadership is a success secret of organizations in performance of the assigned tasks. What leadership style is dominant in multitasking organizations and what leadership style is ideal for increase level of excellence and how and to what extent the mentioned organizations transcend have been less studied. This research was conducted in 2012-2013 considering information gap in research area of Shahid Beheshti University of Medical Sciences. Materials and Methods: The research has been conducted in descriptive method. To study leadership styles, Multi-factor Leadership Questionnaire (MLQ) has been used and to study organizational excellence, EFQM Excellence Model was used. These two questionnaires have been studied on 441 members of faculty board, personnel and students in 21 centers, which provide research services of Shahid Beheshti University of Medical Sciences, which had been selected with cluster random sampling..In this research, mean ranks of 0 to 4 were determined for determining three styles of transformational leadership, transactional and laissez-faire leadership styles and organizational excellence among the studied people based on the maximum 1000 scores (EfQm, version 2010) and correlation between these two factors was specified, analyzed and reported with multiple regression analysis. Results: The most prevalent leadership style in this study was transactional leadership style with rank 3.22 and transformational leadership style with rank 3.16 and finally laissez-faire leadership style with rank 2.95. In other words, profile of dominant leadership style in research area of university is transactional leadership style while this style alone doesn’t play role in organizational excellence of research area (P=0.49 and beta=0.04). On the contrary, transformational leadership style has had absolute effect on excellence (P<0.01 and beta=%37). Mean rank of excellence in the university is 496 and the best rank belongs to Masih Daneshvary Centre and Tuberculosis and Pulmonary Diseases Research Center (605) and the least rank relates to Faculty of Rehabilitation with rank of 395. It is necessary to note that Masih Daneshvary Centre and Tuberculosis and Pulmonary Diseases Research Center have had the highest score together in transformational and transactional leadership style. Conclusion: It seems that: first, excellence in university should be seriously considered and considering that heart research area is motor of scientific development in universities and it should be increasingly considered. Second, although dominant leadership style in university is transactional, it has no acceptable correlation with excellence and it is recommended to study causes and necessary actions for solving the mentioned problem and use transformational leadership style. Keywords: Leadership style, Multitasking organizations, Excellence.
Hiva Kadkhoda, Zohreh Ghalavand, Bahram Nikmanesh, Hamidreza Huori, Donya Taghizadeh Maleki, Gita Eslami,
Volume 42, Issue 1 (3-2018)
Abstract
Background and aim: Staphylococcus is a bacterium responsible for a wide range of diseases, from mild skin infections to lethal necrosis pneumonia. The aim of this study was to determine the virulence factors among methicillin resistant and sensitive strains isolated from clinical specimens of children referred to the pediatric medical center and also to be aware of their antibiotic resistance.
Materials and Methods: In the present study, 100 strains of Staphylococcus aureus, susceptible and resistant to methicillin, were collected during one year. First Biochemical tests were performed to detect Staphylococcus aureus bacteria. Then antibiotic susceptibility test was performed using antibiotic disks (MAST;England) according to CLSI guidelines. The presence of hlg, mecA, nuc and pvl genes was investigated by PCR method and sequenced.
Results: 30 samples (30%) were methicillin-resistant (MRSA) using the cefoxitin disk. The most susceptible to antibiotics, vancomycin with 100% and the highest resistance to antibiotics, penicillin with 98% were determined. The prevalence of hlg, mecA, and pvl genes was 30%, 95% and 6%, respectively.
Conclusion: The present study showed that vancomycin and cotrimoxazole antibiotics were the best effect against MRSA strains.
Saeide Salari, Mehdi Mahmoodi, Masoud Torkzadeh Mahani, Nahid Askari, Mohammadreza Hajizadeh, Nadieh Baniasadi, Dr Reza Malekpour, Alireza Khoshdel,
Volume 42, Issue 4 (12-2018)
Abstract
Background and Aim:
Stomach cancer is one of the most common cancers after lung cancer and the second cause of cancer deaths worldwide. Changes in the expression level of genes are one of the most important factors in cancers. Among them p53 and MICAL-2 were found have changes in their expression levels. P53 gene plays an important role as a tumor suppressor which is also regulates the cell cycle. MICAL-2 encodes monooxygenase which raises F-actin depolymerization. Increased expression of this gene involves the conversion of mesenchymal cells to epithelial which has been associated with metastasis. Considering that the MICAL-2 gene had not been studied with P53 gene at the same time in gastric cancer, this study was conducted to evaluate the expression level of P53 and MICAL-2 genes in stomach cancer patients in Kerman.
Materials and Methods:
A case-control study was designed to determine the changes in the expression level of P53 and MICAL-2 genes. 30 tumor tissues and marginal non-tumor control tissues were obtained from patients. Total mRNA of the samples was extracted, then after cDNA synthesis, Real-Time RT-qPCR, PCR-SSCP as well as sequencing was performed to measure the gene expressions. T-test and ANOVA were used for data analysis.
Results
According to the results, the expression levels of p53 gene were 0.38, 0.47 in cancerous tissues whereas they were 2.04 and 3.11 in normal tissues for exon 6 and 7 respectively. But the results indicated that exons 4 and 5 did not statistically different in normal and cancerous tissues. For MICAL-2 the expression level in the tumor was 2.2 fold increased in comparison to normal tissues. Therefore, it was found that the expression levels of p53 and MICAL-2 genes were significantly higher in tumor tissues compared to those from normal tissues (P<0.05). On the other hand, sequencing results demonstrated missense and deletion mutations in exon 4.
Conclusion:
Regarding to the changes in the expression of P53 and MICAL2 genes in gastric cancer, determination of the expression level in individuals who have family history of this problem, these genes can be used as biomarkers. Because the diagnosis of cancer in the early stages definitely have a better response to therapies.
Shabnam Maleki, Parvaneh Nazarali, Ameneh Razavi, Fahimeh Kazemi,
Volume 42, Issue 4 (12-2018)
Abstract
Background: Obesity is associated with increased risk of many diseases. Methylation is an important factor in obesity, indicating epigenetic changes. However, there is lack of data about PGC-1α methylation and regular exercise. Purpose of this study was to determine effects of 6-week high-intensity interval training (HIIT) on PGC-1α methylation in gastrocnemius muscle of obese male rats.
Methods: In a experimental study, twenty four male Wistar rats were randomly divided into 4 groups (6 rats each): control healthy, trained healthy, control obese and trained obese. Healthy group consumed normal diet and obese group consumed high-fat diet (for 6 weeks). Trained healthy and trained obese performed swimming HIIT for 6 weeks. 24 hours after the last session of the training, gastrocnemius muscle of control and trained rats was extracted and then afterwards PGC-1α methylation was assayed. For analyzing data, paired sample t-test and one-way analysis of variance were used.
Results: After 6 weeks, body weight of trained obese group compared with control obese was decreased significantly (P=0.021). In addition, after 6-week HIIT, PGC-1α methylation of healthy (P=0.010) and obese group (P=0.037) compared with their control group was decreased significantly.
Conclusion: It appears that 6-week swimming HIIT can be effective on obesity state and significantly reduce PGC-1α methylation in gastrocnemius muscle of obese male rats.
Dr Gita Eslami, Donya Taghizadeh Maleki, Dr Zohreh Ghalavand, Dr Bahram Nikmanesh, Dr Ali Hashemi, Hiva Kadkhoda,
Volume 43, Issue 1 (9-2019)
Abstract
Background: Staphylococcus aureus is an opportunistic pathogenic bacterium that can provide invasive
conditions by secreting various toxins. It is involved in the development of skin infections, such as swollen
and ulcers. Today, one of the main problems is the treatment of Staphylococcus aureus resistant strains. The
aim of the current study was to detect virulence factors and antibiotic resistance among strains isolated from
wound infections of children who referred to Tehran Children’s Medical Hospital in 1396-97.
Materials and Methods: A total of 59 strains of Staphylococcus aureus isolated from wound infection were
collected during one year. Staphylococcus aureus was detected using biochemical tests. For antibiotic
susceptibility test, antibiotic disks (Mast، UK) were used according to the CLSI 2017. For detection of
virulance genes, including nuc، mecA، tsst-1، hla، hlb، hld، eta، etb، etc, PCR method was used.
Results: Vancomycin and linezolid were sensitives for all isolates and the highest resistance antibiotic was
penicillin with 98.3%. The frequency distribution of genes s mecA، tsst-1، hla، hlb، hld، eta، etb، and etd were
59.3%, 37.7%, 71.2%, 57.6%, 96.6%, 100%, 11.9%, 27.1%, respectively.
Conclusion: All isolates were sensitive to vancomycin and linezolid, and these antibiotics were the best
choices for the first line of treatment for staphylococcus aureus strains. Since all isolates of Staphylococcus
aureus were obtained from children wound infections and all of them contained oxfolitic A gene, control
and disinfection measures seem to be important among children, because these strains have the potential to
spread this gene among hospitalized patients.
Mina Khoshnoody, Naser Malekpoor,
Volume 43, Issue 2 (7-2019)
Abstract
Background: During the recent years, much attention has been paid to sleeve gastrectomy (SG).
However, it is important to know whether SG really improves the patients' quality of life (QoL). So
far, no study has been conducted in Iranian society in this regard. Thus, in the current study, the
effects of SG on QoL in Iranian patients with morbid obesity was investigated.
Materials and methods: In the present before-after study, the patients with indication of SG who
signed the informed consent were enrolled. The qualified patients included patients with a BMI ≥ 40
Kg/m2 or those with 35 kg/m2 hypertension or cardiac diseases, etc. QoL was measured using WHO-QOL 100 questionnaire. The
questionnaire was completed before the surgery and 6 and 12 months postoperatively.
Results: A total of 100 patients enrolled in the study (51 females and 49 males). BMI decreased
significantly from 6.5±52.5 kg/m2 preoperatively to 5.1±35.4 kg/m2 at the first postoperative day
(p<0.001). The WHO-QOL 100 score increased significantly from 11.4±47.9 to 11.3±82.3 (p<0.05).
Conclusion: It seems that SG is associated with significantly improved QoL after one year. However,
more studies with long-term follow up are required.
Keywords
