Mahdane Roshani, Hossein Goudarzi, Ali Hashemi, Soroor Erfanimanesh, Azim Mehrvar, Maryam Tashvighi, Vahid Fallahazad,
Volume 40, Issue 2 (8-2016)
Abstract
Leukemia is a systemic disease in which the normal mechanisms for producing blood elements impairs. Leukemia, malignant clonal growth of hematopoietic cells, is resulted from a malignant precursor cells. ALL is the most common cancer among children. These patients are prone to get bacterial infections. Serratia marcescens is one of the most common bacterial causes of nosocomial infections and epidemics of a neonatal intensive care units. Case: The patient is a 5-year old boy with leukemia (ALL) who presented to Mahak hospital. He had a history of surgery a few weeks ago and has an arm port in his left arm. Routine urine analysis showed no evidence of abnormalities. Blood culture was positive for Serratia marcescens. The bacteria was also isolated from the culture of port in EMB, blood agar and chocolate agar. Antibiotic susceptibility test was carried out by disk diffusion method according to CLSI guidelines, in which Serratia marcescens was resistant to many antibiotics. Conclusions: Serratia marcescens is an organism that has the ability to cause bacteremia, especially among immune compromised patients and leukemic children.
Dr Nariman Mosaffa, Ms Hoda Rahmani, Ms Somaieh Sadeghi, Mr Mohsen Roshani, Dr Davar Amani, Dr Tooba Ghazanfari,
Volume 43, Issue 1 (9-2019)
Abstract
Abstract
Background: Urban air pollution represents a challenge in Tehran. Health care organs and physicians
pay much attention because of health effect on mankind. Nowadays, a majority of air pollution
related articles focus on particulate matter adverse effects on human health. Epidemiologic studies
show the direct correlation between ambient particulate matter and risk of respiratory system and
cardiovascular disease. However, little attention has been given to the effects of air pollution on
the gastrointestinal system. Emergency system visit increases on polluted days. Recent studies have
shown high incidence of susceptibility to inflammatory bowel diseases (IBD), appendicitis, and
colorectal cancer in the polluted ar eas.
Materials and Methods: We investigated the effect of Particulate matter in two aerodynamic
diameters (PM2.5 and PM10) on peritoneal immune system cells. PM filters of different stations
were purchased from Tehran Air Quality Standard Agency. After harvesting the particles from
corresponding filters, the PMs were cultured with C57BL/6 inbred mice peritoneal macrophages.
MTT test was performed to define the stimulatory and toxic effects of PMs on macrophages.
Results: The results of MTT test showed stimulation of macrophages by PMs. PM2.5 was more
potent in increasing MTT test absorbance. Also, both particles stimulated macrophages in 10μg/ml
concentration in comparison to 5 μg/ml concentration.
Conclusion: These results show particles stimulate macrophages and this stimulation can result in
production of inflammatory cytokines and other macrophage function. In further studies, we will
continue our investigation by evaluating PM effects on pr oducing cytokines and gene expression.
Keywords: Immune system; Macrophage; Peritoneal; Suspended particles of air pollution
