Fereshteh Kamani1, Seyed Sajjad Mohammadi, Mohsen Hassanzadeh, Saba Tavassoli, Ali Ashjae,
Volume 35, Issue 2 (6-2011)
Abstract
Abstract
Background: Lateral sphincterotomy is the standard treatment for chronic anal fissure. In recent years, chemical sphincterotomy by several pharmacological agents, i.e. botulinum toxin, nifedipin, glyceryl trinitrate, has been used as alternative treatment. The objective of this study was to compare the results of botulinum toxin injection with lateral sphincterotomy in patients with this condition.
Methods: In this trial 40 patients were randomized into two groups 19 patients underwent surgical sphincterotomy and 21 cases were treated with injections of 30 units of botulinum toxin into the internal sphincter at 3 different sites (anterior and lateral). Patients were followed for up to 6 months to appraise the results.
Results: There was no significant difference in sex, age, duration of symptoms and anatomical variability of the disease between two groups. The frequency of healing on follow-up visits in the Botox group at 2 weeks, 2 months, 4 months and 6 months was respectively 33.3%, 76.2%, 85.7% and 85.7% and in the sphincterotomy group it was 47.4%, 89.5%, 100% and 94.7%, respectively (p>0.4). None of patients in either groups developed fecal incontinence. The frequency of incontinence to flatus in follow-up visits in Botox group was respectively 38.1%, 19%, 4.8% and 0% and in sphincterotomy group it was respectively 63.2%, 31.6%, 26.3% and 21.1%. The difference in the frequency of flatus incontinence was only statistically significant at the 6th month visit (p=0.04).
Conclusion: Chemical sphincterotomy with injection of 30 units of Botox into the internal sphincter at 3 sites is an effective treatment for chronic anal fissure and accompanied by fewer complications. It is suggested as the primary step in treatment of chronic fissure with surgical sphincterotomy reserved for refractory cases.
KEYWORDS: Botulinum toxin, Chronic anal fissure, Lateral internal sphincterotomy.
Mohsen Sadry, Fereshte Kamani, Reza Asemi, Mehrdad Moghimi,
Volume 42, Issue 4 (12-2018)
Abstract
Background: Gastric carcinoma is one of the most abundant and malignant cancers, and early diagnosis of the disease is very effective in the treatment method and survival rate. In recent years, several genes such as HER-2, which are likely to be associated with prognosis and The prevalence of HER-2 in patients with gastric adenocarcinoma who gastrectomized in survival, have been raised. The aim of this study was to investigate the association and frequency of HER-2 gene expression in patients with gastric adenocarcinoma.
Materials and Methods: In this study, 103 specimens were selected and then the prepared slides were stained by immunohistochemistry and microscopy was used for color variation. The helicobacter counts were evaluated based on the Gimsa test for data analysis of the program SPSS was used.
Results: 34% of HER-2 patients were positive, but 66% did not have this marker. There was no gender or age prevalence in the occurrence of this marker. Also, this study was a correlation between histology grade, increased stage of disease, involvement of lymph nodes, Increased HER-2 incidence in stomach adenocarcinoma patients.
Conclusion: The findings of this study showed a relatively high frequency of HER-2 protein expression in patients with adenocarcinoma of the stomach, but there was no significant correlation between them.
Dr Matin Vahedi, Dr Fereshteh Kamani,
Volume 44, Issue 3 (9-2020)
Abstract
Background and Aim: The aim of this study was to determine the recurrence rate in gastric cancer patients with positive peritoneal lavage cytology in comparison with negative lavage in patients affiliated to Ayatollah Taleghani Hospital.
Materials and Methods: This is a descriptive-analytic study. 59 patients with gastric cancer are included in the study. Lavage of peritoneal cavity is performed with 150 cc of saline tare. 4 LAMs are provided from each patient.
Postoperative follow-up of patients after recurrence of the disease regardless of the stage of the disease in patients with cytological lavage positive and negative.
Results: In this study, 59 patients were diagnosed with gastric cancer, 20 men and 39 women. The results of the study showed that there is a significant relationship between peritoneal fluid cytology and relapse (P value = 0.001).
Conclusion : In this study, the peritoneal cytology value in determining the prognosis of stomach, colon, and pancreatic cancers was more studied and the relationship between positive cytology of peritoneum lavage and inappropriate prognosis was confirmed. This method has also been used to determine the relapse of abdominal cancers, which has had beneficial results.
