Showing 6 results for moghimi
Mt Salehian, M Mehrdad, M Moghimi, M Hosseinzadeh Malek,
Volume 30, Issue 4 (12-2006)
Abstract
Primary hyperparathyroidism is a quite frequent disorder however, giant parathyroid adenoma is a rare entity. We described a 39-year old woman presenting with lower extremities bone pain within the recent 3 years. She had been receiving levothyroxin during the past 10 years due to hypothyroidism, meanwhile, she had a bulge right thyroid lobe. Laboratory examinations revealed she was euthyroid, however, scanning showed parathyroid adenoma. During surgery, an adenoma measured 2×3×6cm, weighted 22gr was resected. Giant parathyroid adenoma present with non-characteristic symptoms, thus, routine laboratory measurements including serum calcium and phosphorous should be proposed for suspected individuals.
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Montazer Haghighi M, Najjar Sadeghi R, Najjar Sadeghi R, Khatami F, Moghimi Dehkordi B, Ghiasi S, Zali Mr,
Volume 32, Issue 3 (fall 87 2008)
Abstract
Background and Aim: Colorectal cancer is one of the most common malignancies in worldwide. Because the gene 5, 10-methylene-tetrahydrofolate reductase (MTHFR) plays a key role in methylation, synthesis and repair of DNA, numerous studies have focused on evaluating the correlation between polymorphisms of this gene and sporadic colorectal cancer. This study was carried out to examine the association of MTHFR gene polymorphism, C677T, with non-familial colorectal cancer in an Iranian population.
Material and methods: We analyzed peripheral blood samples of 118 cases of colorectal cancer and 189 controls by pyrosequencing method. Controls were subjects who had been referred to our center during the study period and had revealed normal findings on colonoscopy
Results: We found that frequency of CC, CT and TT genotypes among the colorectal cancer patients were 51.7%, 28% and 20.3% respectively. The figures for controls were 47.1%, 27% and 25.9% respectively.
Furthermore, allele frequency T in the cases was 34% and allele frequency C was 66% while allele frequency T in controls was 39% and allele frequency C was 61%.
Conclusion: Interestingly we observed a reverse association between risk of colon cancer with 677TT genotype.
Mohammad Hassan Bahrami, Seyed Mansour Rayegani, Amin Azhari, Hamid Reza Moghimi, Naser Valaei, Daryoush Elyaspour, Masoumeh Bayat,
Volume 34, Issue 3 (11-2010)
Abstract
Abstract
Background: EMG needling is not a painless procedure. In recent studies it has been shown that a form of lidocaine has the efficacy which is similar to EMLA, for prevention of pain associated with EMG needling. The aim of this study was to evaluate the efficacy of Lidocaine H ointment in alleviating the pain caused by EMG needling. This study was performed on patients referred to Shohadaye Tajrish Hospital for EDx study in APR 2009- APR 2010.
Methods: A double blinded, placebo controlled study was performed in 47 adult patients (94 lower limbs) to compare the pain of EMG needling into the tibialis anterior muscle after application of lidocaine-H ointment or placebo. Pain scores were obtained by using visual analog scale (VAS). Experimental and placebo groups were compared with Mann-U-Whitney and Chi-square tests.
Results: The study was performed on 47 patients, 38.3% male & 61.7% female, mean age being 45.5 ± 16.4years. Median VAS score was 4.66 ± 2.14 vs. 6.11 ± 2.07, (P<0.05). 51.1% of patients in experimental group as compared to 21.3% in controls reported mild pain (VAS < 4), (P<0/01).
Conclusion: It seems that lidocaine-H ointment has beneficial effects in prevention of the pain associated with EMG needling.
Keywords: Lidocaine-H ointment, Pain, EMG needling.
Peyman Bakhshaei, Mehrdad Moghimi,
Volume 40, Issue 4 (1-2017)
Abstract
Background: Despite the long-term survival in papillary thyroid cancer (PTC), cervical lymph node metastasis is the most important factor in regional recurrence of the disease. The aim of the present study was to find clinical risk factors for microscopic metastasis to the lymph nodes, without involvement of the neck lymph nodes.
Methods: medical records of 115 PTC patients who underwent total thyroidectomy surgery in Ayatollah Taleghani Hospital of Tehran during 2015-2016. Study variables included age, gender, tumor size, multifocality of tumor, tumor location and tumor extension to thyroid capsule, and metastasis. Data were analyzed using SPSS v20 software.
Results: The incidence of metastasis was 49%. A weak positive correlation was observed between age and metastasis, and a very weak correlation between the tumor size and metastasis. The calculated cut-off point for age was 42.5 years and for tumor size, 1.75 cm (sensitivity 58% and specificity 57%). The metastatic was more common in men than women and in the multifocal tumors than single focal tumors. Metastasis was associated with tumor location and tumor extension to the thyroid capsule.
Conclusion: It seems that older age, larger tumor size, male gender, multifocal tumor, extension of tumor invasion to the capsule could be predictive risk factors of lymph node metastasis in PTC patients, and therefore, prophylactic central lymph node dissection may be considered in the patients who have several of these factors. Also, post-operative follow-up for recurrence should be performed more accurately and in a shorter time interval in these patients. However, more studies should be done in the future.
Naghmeh Moghimi, Akram Eidi, Pejman Mortazavi, Ali Haeri Rohani,
Volume 42, Issue 2 (6-2018)
Abstract
Background & Objectives: Magnesium (Mg
2+) is the second most abundant cation (after potassium) in the cell and plays an important role in various biological functions, including cell cycle, channel regulation, ATPase activity, metabolic regulation, etc.
Magnesium deficiency increased incidence of cardiovascular diseases, including hypertension, stroke and atherosclerosis,
and gastrointestinal disorders, such as loss of appetite, nausea, and vomiting. Considering the antioxidant activity of magnesium and role of oxidative stress in the pathophysiology of epileptic seizures, the present study was designed to investigate the effect of magnesium sulfate on pentylenetetrazole (PTZ)-induced seizures was investigated in adult male Wistar rats.
Methods: The present research is an experimental method. The rats were randomly divided into 8 groups: normal control, magnesium sulfate (0.05, 0.1, and 0.2 g/kg intragastrically, daily) alone, seizuric control rats (PTZ, 35 mg/kg, i.p.), magnesium sulfate (0.05, 0.1, and 0.2 g/kg intragastrically, daily) together with PTZ, and treatment was performed accordingly. Administration of magnesium sulfate (0.05, 0.1 and 0.2 g/kg) was started 1.5 h before the first dose of PTZ and continued up to 28 days. The rats were sacrificed on day 29 and parameters of oxidative stress, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX) and malondialdehyde (MDA) activity, were measured in liver homogenate.
Data were evaluated by one-way analysis of variance.
Results: Administration of magnesium sulfate (0.1 and 0.2 g/kg) significantly increased the levels of antioxidant enzymes, including SOD, CAT, GPX, while decreased MDA levels
(p<0.05).
Conclusion: It seems that presumably magnesium sulfate is effective in providing protection against oxidative stress induced by PTZ.
Mohsen Sadry, Fereshte Kamani, Reza Asemi, Mehrdad Moghimi,
Volume 42, Issue 4 (12-2018)
Abstract
Background: Gastric carcinoma is one of the most abundant and malignant cancers, and early diagnosis of the disease is very effective in the treatment method and survival rate. In recent years, several genes such as HER-2, which are likely to be associated with prognosis and The prevalence of HER-2 in patients with gastric adenocarcinoma who gastrectomized in survival, have been raised. The aim of this study was to investigate the association and frequency of HER-2 gene expression in patients with gastric adenocarcinoma.
Materials and Methods: In this study, 103 specimens were selected and then the prepared slides were stained by immunohistochemistry and microscopy was used for color variation. The helicobacter counts were evaluated based on the Gimsa test for data analysis of the program SPSS was used.
Results: 34% of HER-2 patients were positive, but 66% did not have this marker. There was no gender or age prevalence in the occurrence of this marker. Also, this study was a correlation between histology grade, increased stage of disease, involvement of lymph nodes, Increased HER-2 incidence in stomach adenocarcinoma patients.
Conclusion: The findings of this study showed a relatively high frequency of HER-2 protein expression in patients with adenocarcinoma of the stomach, but there was no significant correlation between them.
