Showing 5 results for Metabolic Syndrome
, , , , Hossein-Panah F, Sadeghi L, Rambod M, Foroutan M, Naseri M ,
Volume 30, Issue 1 (3-2006)
Abstract
Background: Non-alcoholic fatty liver disease (NAFLD) is a relatively prevalent disorder with many suspected risk factors. The aim of this study was to assess the association between the suspected risk factors with the presence of NAFLD according to the ultrasonographic criteria in type II diabetic patients.
Materials and methods: The study was performed on 76 type 2 diabetic patients attending consecutively to endocrine clinic. Negative history of alcohol use and hepatitis B and C were our basic inclusion criteria. All candidates underwent thorough clinical and biochemical assays consist of height, weight, waist circumference, fasting blood sugar, HbA1c, triglyceride, total cholesterol, HDL and LDL, liver trans-aminases, alkaline phosphatase, thyroid function tests, serum iron and total iron binding capacity and liver sonography to detect the presence (stage I to III) or absence of steatosis. The score of metabolic syndrome was determined according to the latest ATP III criteria. Pearson and Spearman correlation coefficients and logistic regression were used to assess the relationship between suspected risk factors and the presence of NAFLD.
Results: Forty-nine patients (64.4%) were female. The mean age (± standard deviation) was 59.7±8.8 years. The mean BMI in patients with and without NAFLD were 29.4±4.5 and 24.8±3.8kg/m2, respectively (p<0.001). Prevalence of NAFLD was significantly higher among patients with metabolic syndrome (89% vs. 43%, p<0.05). Age (r=-0.24, p<0.05), waist circumference (r=0.27, p<0.05) and triglyceride (r=0.28, p<0.05) had significant correlation with steatosis. However, in logistic regression analysis, only BMI (for each 5 unit increment) was independently associated with the presence of NAFLD (OR=4.25, 95%CI: 1.7-10.9, p<0.05).
Conclusion: In type 2 diabetic patients, only BMI had a significant role in predicting NAFLD. It seems that other metabolic factors will not give any additional information for predicting NAFLD.
M Mehrdad, F Hosseinpanah, F Azizi,
Volume 30, Issue 4 (12-2006)
Abstract
Background: The metabolic syndrome is a constellation of risk factors that increase the incidence of cardiovascular disease and type 2 diabetes mellitus in adults. Some studies in recent years have found evidence of initiation of this disease in childhood and of the association of childhood obesity with adult cardiovascular disease and diabetes. The present study was carried out to determine the prevalence of risk factors for metabolic syndrome in children, in order to prevent, or at-least decrease the occurrence of fatal cardiovascular and diabetic complications.
Materials and methods: In a cross-sectional study within the framework of the Tehran Lipid and Glucose Study (TLGS), 1067 children, 3-9 years of age, including 506 boys and 561 girls were investigated. Weight and height was measured and BMI calculated. Fasting blood samples for the measurements of glucose and lipid concentrations were drawn. A qualified physician measured blood pressure three times in a seated position using a standard mercury sphygmomanometer and the mean of three measurements was considered as the participant’s blood pressure. After gathering the results of basic measurements, all results, except blood pressure were matched with Iranian tables of percentiles of BMI and lipids for age and sex. For blood pressure we used the world wide accepted NCHS tables. ‘At risk of overweight’ was defined as ≥85th to <95th percentile of BMI for age and sex. Subjects with three or more characteristics of the following components of metabolic syndrome were categorized as having the syndrome (1) BMI≥95th percentile for age and sex (2) TG≥95th percentile for age and sex (3) HDL cholesterol <5th percentile for age and sex (4) Impaired fasting glucose (FBS between 100-125 mg/dl) (5) systolic/ diastolic blood pressure>95th percentile for age, sex, and height.
Results: Prevalence of metabolic syndrome was 0.9 percent, (95%CI:0.3-1.5) overall, 8.9 percent in overweight youngsters, 0.3 percent in at risk of overweight and only 0.1 percent in the normal weight group. Prevalence increased with increases of body-weight with a significant difference between overweight children and other BMI groups. Overall, 12 percent of children were at risk of overweight, 8.4 percent were overweight, with no significant difference between two sex groups. Most prevalent components of metabolic syndrome in overweight children were hypertension and high TGL, (14.4%) low HDL and impaired fasting glucose were next in order of frequency. In comparison with subjects with normal weights, the difference in hypertension was significant in overweight children, (P<0.01).TGL was significantly different from normal weight group (P<0.01) and also with at risk of overweight (P<0.05).
Conclusion: This study showed a low prevalence of metabolic syndrome among Iranian children but the prevalence of this syndrome in overweight youngsters was significantly higher than other BMI groups. The prevalence of at risk of overweight of 12 percent on one hand, and the high rate of transition of overweight children into obese adults in subsequent years of life on the other hand, is alarming. Special attention to weight control through nutritional counseling and increased physical activity during childhood and adolescence is recommended.
Somayeh Hosseinpour-Niazi, Parvin Mirmiran, Zahra Naderi, Mahbobeh Sadeghi, Fereidoun Azizi,
Volume 35, Issue 4 (2-2012)
Abstract
Abstract
Background: Limited observational studies have investigated the association between dietary PUFAs and the metabolic syndrome. The aim of this study was to examine the association between the dietary ω-3 fatty acids including α-linolenic acid (ALA), Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA) and ω-6 PUFAs, the interaction and ratio of these dietary PUFAs and the metabolic syndrome and its components.
Methods: This was a population-based cross-sectional study within the framework of Tehran Lipid and Glucose Study, conducted on 2457 participants with mean age of 39.1 ± 13.4 years. Information about the intake of different polyunsaturated fatty acids by the participants was obtained through a 168-item food frequency questionnaire. Fasting plasma glucose (FPG), triglyceride and HDL cholesterol concentrations and blood pressure were measured. Metabolic syndrome was defined according to recommended by the Adult Treatment Panel III.
Results: After controlling for potential confounders, multivariate-adjusted odds ratio of hypertriglyceridemia between highest and lowest intake of dietary PUFAs were 0.58 for ω-6 fatty acids, 0.61 for ALA, and 0.51 for EPA + DHA. Inverse relationship was found between abdominal obesity and intake of ALA, (OR=0.54) and, ω-3 fatty acids, (0.52). Higher intakes of ω-6 fatty acids and ALA were associated with lower frequency of the metabolic syndrome. Higher ALA intake was associated with a 28% lower risk of the metabolic syndrome among subjects irrespective of their intake of ω-6 fatty acids.
Conclusion: ALA intake reduced the prevalence of metabolic syndrome, irrespective of intake of ω-6 fatty acids. More studies are needed to determine the association between dietary source of these fatty acids and the metabolic syndrome and its components.
Keywords: Metabolic syndrome, Polyunsaturated fatty acids, Dietary ratio of ω-6/ ω-3.
Behrooz Navayinia, Sara Asgharian, Shiva Rahimipour_anaraki,
Volume 44, Issue 1 (3-2020)
Abstract
Background: Rheumatoid arthritis is a chronic inflammatory disease associated with an increased risk of atherosclerotic disease. Cardiovascular disease is the leading cause of mortality in RA patients. Understanding the risk factors affecting the chance of developing metabolic syndrome can reduce cardiovascular mortality and morbidity in RA patients.
Materials and Methods: This cross-sectional study was performed on 200 patients with RA according to ACR classification from patients referred to rheumatology clinic of Imam Khomeini Hospital from October 2013 to September 2013. The main outcome of the study was the prevalence of metabolic syndrome based on two criteria of the International Diabetes Federation and the Iranian definition. Secondary outcomes The prevalence of different components of the metabolic syndrome and the association of different demographic, anthropometric, laboratory and medication variables of RA patients with the chi-square test were statistically analyzed
Results: Metabolic syndrome was significantly associated with cigarette smoking. Among the medications used in RA patients, prednisolone (glucocorticoids) and azathioprine were associated with a significantly increased chance of developing metabolic syndrome. (P˂0.05) and no significant relationship was found between metabolic syndrome and inflammatory factors CRP;or ESR, anti CCP, and RF. But the level of DRA in patients with metabolic syndrome was lower than in others. (P˂0 / 05)
Conclusion: Metabolic syndrome is highly prevalent in patients with RA. Considering the risk factors responsible for the increased risk of metabolic syndrome in this potentially high-risk population
Mrs Kobra Rasi, Dr Bahloul Ghorbanian, Dr Asgar Iranpour,
Volume 47, Issue 3 (12-2023)
Abstract
Background and Aim: Inhibition of myostatin as a myokine is involved in reducing fat accumulation through increasing muscle mass. The aim of this study was to investigate the effect of an aerobic exercise course on myostatin levels and metabolic risk factors in middle - aged men with metabolic syndrome.
Methods: Thisresearch was an experimental study with a pre - test and post - test design. 20 men with metabolic syndrome and average age of 53.6 ± 3.13 years voluntarily participated in this study and were randomly divided into two control (n= 10) and aerobic exercise (n= 10) groups. The assimilation of the subjects of the two groups was done based on the inclusion criteria and random selection of the subjects in the groups. The exercise program included 12 weeks of aerobic exercise with a sequence of 3 sessions per week and each session included 45 minutes of exercise with an intensity of 60-70% of reserve heart rate. During the intervention period, the control group only did their daily activities without exercising. All research variables such as myostatin levels, metabolic factors and body composition, and maximum oxygen consumption were measured in two stages before the training intervention and 48 hours after the last training session. Statistical analysis of the data was done by independent and dependent t-tests.
Results: There was a significant difference between the two training and control groups in all research variables (P ≥ 0.05). Myostatin values (P= 0.001), HDL (P= 0.001), VO2max (P= 0.001) significantly increased and the values of body weight (P= 0.001), BMI (P= 0.001), waist size (P= 0.001), mean blood pressure (P= 0.001), total cholesterol (P= 0.001), triglyceride (P= 0.002), LDL (P= 0.001), blood sugar (P= 0.001) ) and insulin resistance index (P= 0.001) in the exercise group decreased significantly in the post-test compared to the pre-test.
Conclusion: It seems that a 12-week aerobic exercise program with an intensity of 60-70% of reserve heart rate could be suggested as a non-drug method to reduce myostatin and control metabolic risk factors in patients with metabolic syndrome.
