Respiratory Distress Syndrome, which was previously known as Hyaline Membrane Disease (HMD), is among the most common cause of immature neonatal death. The present study has discussed the disease history, pathophysiology, clinical manifestations, laboratory findings, radiologic findings, and differential diagnosis. Meanwhile, recent progresses achieved in the field of treatment using surfactant or modern techniques of mechanical ventilation were mentioned. Prevention and future perception were also discussed.