Showing 2 results for Side Effects.
Talari Sa , Afzali H , Khalifehsoltani A ,
Volume 27, Issue 1 (3-2003)
Abstract
Background: Giardia lamblia is a common intestinal parasite associated with social or personal problems. With respect to the controversies regarding the efficacy and side effects of Metronidazole, Furazolidone and Paramomycine, the present study was conducted on adults infected by Giardia lamblia.
Material and methods: 210 individuals infected with giardia lamblia were assigned in 3 groups. They were 15-45 years old. Patients were surveyed one and four weeks following the therapy with Metronidazole, Furazolidone and Paromomycine. Results were compared using chi square method.
Results: Of 210 infected patients, 53.3% were urban residents, 44.6% were males and 51.4% were females. Infection was more commonly found in illiterates (46.7%), whereas it was less commonly observed in educated subjects (6.7%). Diarrhea was the most prevalent clinical sign (89.5%). Four weeks after the therapy, the efficacy of Metronidazole, Furazolidone and Paromomycine were 90, 81.4, 64.3%, respectively. Metallic taste (17.2%), darking of urine (18.6%) and tenesmus were the most frequent side effects of Metronidazole, Furazolidone and Paromomycine, respectively.
Conclusion: With respect to the varied efficacy of antihelmentic drugs in the treatment of Giardiasis, further studies in different part of the country are highly recommended.
Mohammad Rahmati Roodsari, Leyla Gorgzadeh, Hakimeh Zali,
Volume 36, Issue 5 (2-2013)
Abstract
Abstract
Background: Toxic epidermal necrolysis (TEN) and Stevens Johnson syndrome (SJS) are diseases that may cause serious complications. This study aims to describe the cause, clinical course and complications in patients admitted with TEN and SJS in two university hospitals in Tehran.
Materials and methods: Patients admitted with TEN or SJS in Shohada and Loghman hospitals between 2000 and 2006 were included in the study, and the causes, complications and mortality of these two diseases were documented.
Results: Out of the 59 patients studied, 93% of patients were diagnosed as SJS and 7% with TEN 52.5% were male. 73% of patients were adults and 17% children. Over 80% of patients had received at least one of the two classes of drugs, i.e. antibiotics and/or anticonvulsants. Infectious disease had been diagnosed in 39% of patients and epilepsy in 55%. Next on the list were migraine, head trauma, intracranial hemorrhage and uremia. The mean duration of drug use was 26.5 days. 23.7% of patients had anemia and 15.2% patients had leukopenia. In 11.8% of patients liver transaminases were increased 27.3% had pyuria, 11.8% hematuria, and 10.2% had both pyuria and hematuria.
Conclusion: The study showed that many factors are involved but drug use is the most important factor that causes TEN/SJS.
Keywords: Toxic epidermal necrolysis, Stevens Johnson syndrome, Epilepsy, Drug, Side effects.
