Showing 6 results for Endurance Training
Fariborz Hovanloo, Mehdi Hedayati, Maryam Ebrahimi, Hossein Abednazari,
Volume 35, Issue 1 (5-2011)
Abstract
Abstract
Background: Anti oxidative enzymes activity is an important issue in oxidative stress. Most previous researches have dealt with the effect of brief and anaerobic exercise on these enzymes the purpose of this study was to determine the alterations of antioxidant enzymes viz. superoxide desmutase, catalase and glutathione (SOD, CAT, and GPX) activity after endurance training in rat liver tissue.
Methods: In this experimental study, 62 male Wistar rats were selected randomly and divided into 3 control and 3 experimental groups. Experimental rats trained for 6, 9 and 12 weeks, 5 days/week running on treadmill with initial speed of 10 m/min for 10 minute to the ultimate speed of 25 m/min for 60 minute. For control groups the protocol was walking on treadmill with 10 m/min speed for 3 days/ week. After each course (6, 9, 12 wk.), rats were anesthetized and samples taken from the livers of all animals in the study. Determination of antioxidant enzymes activity was done with enzymatic color assay method.
Results: The results showed that 6, 9 and 12 weeks of endurance training have no significant effect on GPX activity. Also, 6 and 9 weeks of endurance training did not alter the activity of SOD and CAT in liver tissue, but, 12 weeks of endurance training decreased SOD and CAT activity significantly, (CAT activity in experimental group was 23.11 ± 7.27 U/mL and in control group it was 31.43 ± 7.21 U/mL SOD activity in experimental group was 47.70 ± 0.56 U/mL and in control group it was 48.20 ± 0.48 U/mL, (P<0.05)).
Conclusion: Results of this study reveal that participating in 9 weeks of moderate exercise does not have detectable effects on the anti oxidative system, but when the exercise continues until 12 weeks, it decreases the SOD and CAT enzyme activity.
Keywords: Endurance training, Superoxide dismutase, Catalase, Glutathione peroxidase, Liver, Rat.
Dr Rahman Soori, Miss Fatemeh Mahmoudi, Dr Azam Ramezankhani, Mr Kia Ranjbar,
Volume 41, Issue 1 (4-2017)
Abstract
Background: Appetite-regulating hormones play an important role in energy balance. Nesfatin-1 and
Neuropeptide Y are orexigenic and anorexigenic peptides that play an important role in obesity and energy
balance. The aim of this study was to assess the effects of endurance training on serum levels of nesfatin-1,
neuropeptide Y and cortisol in sedentary obese men.
Methods: In this experimental study, 30 men aged between 48 to 60 years with BMI≥30 kg/m2, were randomly
allocated to the endurance training and control groups. The training program consists of 12 weeks of endurance
training (treadmill running) with 50-75% maximum heart rate. Blood samples were withdrawn before and 48
hours after the 12 weeks exercise for measurement of nesfatin-1, neuropeptide Y, cortisol and some inflammatory
factors were performed. Paired sample t-test and ANCOVA were used for statistical analysis.
Results: Results revealed that after 12 weeks endurance training, the levels of cortisol decreased significantly
(p=0.015). Reduction in serum nesfatin-1 was observed whereas these changes weren’t significant (p=0.060).
There was no significant change in neuropeptide Y (p=0.307). Also, a significant reduction in anthropometric
indices was observed in training group.
Conclusion: According to the findings of this study, it can be concluded that 12 weeks of endurance training,
despite the impact on cortisol, has no significant effects on neuropeptide Y and nesfatin-1.
Sadeghipour, Mohsen Salesi, Maryam Koushki Jahromi, Javad Sajedian Fard, Samad Akbarzadeh, Parviz Farzadinia,
Volume 42, Issue 2 (6-2018)
Abstract
Background: Betatrophin known as new therapeutic target of pancreases tissue. The aim of this study was to investigate the effect of endurance training program on betatrophin serum concentrations and pathological changes of pancreas tissue in diabetic rats.
Material and Methods: Male wistar rats (N=24) divided in 3 group include healthy control, diabetic control and endurance training. After induction of diabetes, training group performed 4 weeks endurance training and betatrophin concentration was assessed by ELIZA and The pancreatic tissue was evaluated via histological method.
Results: Results showed that betatrophin serum concentration significantly decreased in diabetic control group (P≤0.05) but there was no significant increases observed in training group (P≥0.05). Compared with diabetic control groups, endurance training didn’t make any significant changes in insulin resistance and beta cell function (P≥0.05). In endurance training group, the mean of number and size of pancreatic islets and number of β-cell was higher than diabetic control group.
Conclusion: Although endurance training didn’t able to significantly increase the betatrophin levels but it had a positive effect on the pancreatic tissue in diabetic rats
Dr Sediqeh Jalali, Dr Mohsen Jafari,
Volume 43, Issue 4 (12-2019)
Abstract
Background and Aim: ABCG5 and ABCG8 are two membrane cholesterol transporters involved in transportation of this substance across the membranes of hepatocytes and enterocytes. The aim of the present study was to investigate the effects of continuous and interval trainings on gene expression of these substances in hepatocytes of male wistar rats.
Methods and Materials: In the current experimental study, 15 rats were assigned into groups of control with high fat diet (group 1, N=5), interval training with high fat diet (group 2, N=5), and continuous training with high fat diet (group 3, N=5). Duration of trainings was 12 weeks (5 days/week). Mann-Whitney U test was used for statistical analysis of data.
Results: The results showed that ABCG5 and ABCG8 genes expression after trainings were higher in groups of 2, 3, and 1, respectively. As for ABCG5, differences between groups 1 vs 2, 1 vs 3, and 2 vs 3 and for ABCG8, differences between groups 1 vs 2 and 2 vs 3 were significant (P=0.008) and only the difference between groups 1 vs 3 regarding ABCG8 was non-significant (P=0.841).
Conclusion: It seems that exercise trainings are more effective on ABCG5, as compared with ABCG8 gene expression, and HIT is more effective compared with continuous trainings, on liver cholesterol excretion during reverse cholesterol transport.
Ms Masoume Sedighi, Dr Jabbar Bashiri, Dr Alireza Nourazar, Dr Hamdollah Hadi,
Volume 45, Issue 3 (9-2021)
Abstract
Background and Aim: Nowadays, considering the occurrence of various diseases as a result of inflammation, finding a solution for inflammations caused by various factors is very important. Therefore, the aim of the present study was to investigate the effect of eight weeks of endurance training and complementation on the levels of CD22 and TRL4 in obese wistar rats.
Materials and Methods: In an experimental study, 40 Wistar rats of two-month age range, were purchased from Pasteur Institute of Karaj and divided into four groups (each group including 10 animals) of high-fat diet without intervention, endurance training group, only olive supplement, and the olive supplement group with endurance training. Animals in the training groups underwent a two-month endurance training program (80% maximal oxygen consumption). Also, in the olive oil supplement group, one gram of olive oil per kg body weight was fed daily through oral gavage. ELISA method was used to evaluate serum TLR4 and CD22 levels, Shapiro-Wilk test was used to evaluate the normal distribution of samples, and one-way and two-way ANOVA were run for the purpose of between groups comparisons (p<0.05).
Results: The results showed that two months of endurance training alone do not have a significant effect on inflammation )TLR4 (P=0.09), CD22(P=0.16)) in obese male Wistar rats. However, consumption of olive oil alone significantly reduced TLR4 (P = 0.009) and CD22 (P = 0.008). This is while two months of endurance training with oil consumption had no significant effect on TLR4 (P = 0.09) and CD22 (P = 0.10).
Conclusion: It seems that consumption of olive oil can reduce obesity-induced inflammation (TLR4) to some extent. However, further research is needed to fully reveal this.
Mr Mojtaba Khansooz, Phd , Phd Mohamadreza Palizvan, Phd Abbas Saremi,
Volume 45, Issue 4 (12-2021)
Abstract
Background: In patients with myocardial infarction, preventing the deposition of lipoproteins in the vascular wall is an important factor in rapid recovery and functional capacity returns doing exercise. Therefore, the aim of the present study was to investigate the effect of increasing endurance training on the risk of cardiovascular risk factors in infant specimens.
Materials and Methods: A total of 20 Wistar rats aged 8-10 weeks with a mean weight of 230±30g were divided into two groups of infarction control (MI.Co) and infarction (MI.Ex). After inducing experimental myocardial infarction with two intraperitoneal isoproterenol injections at a dose of 150 mg/kg for 24 hours, the exercise group performed an endurance training protocol on the treadmill for eight weeks. Applying the same conditions followed at least 24 hours after the last training session. To examine the significant changes in the levels of Cholesterol, TG, LDL, and HDL, independent t-tests were run in Graph Pad program.
Findings: Serum LDL and TG levels in the infarct training group decreased significantly (2.12 and 13.87 mg/dl, respectively) compared with the infarct control group (p=0.03). However, cholesterol and HDL levels increased in the infarct training group, as compared with the infarct control group (5.25 and 4.12 mg/dl, respectively), which was observed to be significant only in HDL levels (p=0.03).
Conclusion: It seems that the use of non-pharmacological strategies, such as increased endurance training, can significantly reduce LDL and TG levels and, in turn, significantly increase HDL levels in patients with myocardial infarction.
