Research in Medicine

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Background: Lichen planus is a mucocutaneous inflammatory disease with adnexal involvement. Pathologic studies were commonly used for definite diagnosis. Hyperkeratosis, hyper granulosis, acanthosis, elongation of rete ridges, basal cell degeneration and bank like lymph infiltration are 6 histopathological findings in diagnosis of lichen planus. Materials and methods: In this research 200 pathological reports of patients with lichen planus (114 males and 86 females) have been studies. Results: Lymphocytic infiltration (band like or focally) was the most common findngs, wheras intact basal layer was the rarest finding. In 60 patients the diagnosis was confirmed by the 6 classic histopathological findings. Sampling was performed in 18% of the patients form mucosal lesions. Histopathologic findings have shown no significant correlation with age and sex. Focal degeneration of basal layer and focal infiltration of lymphocyte in mucosal lesions have shown significant increase as compared with skin lesions (p<0.05). Conclusion: Unfortunately, the pathologic studies of lichen planus encountered lots of problems. Further studies are strongly suggested.

Keywords: Lichen planus, Pathology, Diagnosis

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