Accumulated data based on experiences with curtico,teroids in the management uf infectious diseases, have proved that they are very dfective and ,afe drugs provided that are administered properly.
The Corticosteroids arc administered mainly bec,1usc o; antitoxic, antiimflammatory a11d antiallcrgic effects, the cndotoxius are ncuturalized, generalized body reactions are diminished, damaged tissues arc repaired and tissue fibrosis and sdcrosis arc prevented, thry are used in the treatment of diseases manifested with severe toxic state, involvement ofsupra renal glands, allergic reactions, exudation and severe ,;ibrosis.
The corticosteroids of choiceare prednisolone and in some cases Hydrocortisone hemisuccinate, dosage is dependent on severity of the disease and usually it ranges bdween 0.512 mk./kg/24hrs. prednisolonc and equalent dose of H.CH, depending on sev-erity of the disease, duration of treatment should be considered.
The main indications o[ corticosteroids are as follows:
Infectious diseas2s : Typlwid fever, Brurcllo,is, Septicemia, Purulent meningitises, some cases of T.B., Rheumatic fever, Viral hepatitis, Infectious mononucleosis, complications of Influenza and .Mumps (Orchitis)., Edematous laryngitis in children, Viral ca rdiopa thies, Post vaccination encephalitis, Toxoplasmosis, Malaria (Cerebral), and rarely in Ricketsil infections.
Management of allergic reactions (Scrum seactions).