Volume 44, Issue 4 (6-2020)                   Research in Medicine 2020, 44(4): 562-566 | Back to browse issues page

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Barouti E, Nemati S. Impact of probiotic supplement (LactoFem) on Glycemic Control, Lipid profile and pregnancy out comes in women with Gestational Diabetes. Research in Medicine. 2020; 44 (4) :562-566
URL: http://pejouhesh.sbmu.ac.ir/article-1-2003-en.html
, saramti@yahoo.com
Abstract:   (1786 Views)

Background: gestational diabetes mellitus (GDM) is one of the common metabolic diseases among pregnants that needs delicate monitoring and control to improve the metabolic condition and reduce pregnancy complications. Despite scarce data on the effect of probiotic supplementation on glycemic control and serum lipids concentrations in women with GDM, probioticsupplements and their effect on pregnancy outcome has become the center of focus in research. We aim to determine the impact of probiotic supplementation on glycemic control, lipid profiles, pregnancy, and infancy outcomes in GDM patients. 

Method: in this clinical trial study, 120 GDM patients underwent a specific diet. Patients are divided into two separate groups to receive either probiotic supplements (N=60) or a matching placebo (n=60). Through the study group, nutrition counseling performed and the patients received treatment for 6 weeks. Demographic characteristics (age of participants, gestational age, gravidity, and BMI) evaluated and serum levels of fasting blood sugar (FBS), Triglyceride, Total cholesterol, LDL cholesterol, HDL cholesterol examined before and after the intervention, respectively. Besides, Weight of newborn infants, Apgar scores, the requirement of using insulin among pregnants, and pregnancy outcomes examined carefully. SPSS version 20 (SPSS Inc., Chicago, IL, USA) software was used for statistical analysis. 

Results: there were no significant differences in demographic characteristics criteria between the two groups. All the participants were in the early second trimester period. After 6 weeks of intervention, probiotic supplementation resulted in a significant decrease in FBS (p=0.01) and the requirement for insulin administration was significantly lower in comparison with the control group (P=0.026). In addition, we observed elevated lipid profiles in both groups. A significant rise in serum HDL (P=0.01) was seen following supplementation with the probiotics and a significantly elevated serum level of LDL was seen in the control group (P=0.01). In the group with the probiotic supplementation diet, the weight of newborn infants (P=0.001) and pregnancy complications (P=0.028) were also significantly lower in comparison with the control group.

Conclusion: the result of our study demonstrated that using probiotic supplements in women with GDM had beneficial effects on glycemic control, reduce the requirement of insulin treatment, serum LDL cholesterol concentration, serum HDL cholesterol concentration, and less adverse pregnancy and infancy outcomes

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Type of Study: Original | Subject: Gynecological and Obstetrical
Received: 2019/04/5 | Accepted: 2020/03/10 | Published: 2020/06/27

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