Volume 13, Issue 1 And 2 (September 1989)                   Research in Medicine 1989, 13(1 And 2): 43-54 | Back to browse issues page

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Azizi F. Altered Receptors. Research in Medicine. 1989; 13 (1 and 2) :43-54
URL: http://pejouhesh.sbmu.ac.ir/article-1-2480-en.html
Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract:   (1982 Views)
Receptor disorders may produce specific clinical manifestations resembling hypo-or hyper-function of related endocrine gland. Receptor disorders can be divided into five categories: 1)Altered receptor concentration exists in insulin resistance seen in obsity, familial hypercholes­terolemia and in testicular feminization. 2) Altered receptor affinity can be seen in fasted obese patients, acromegaly and insulinoma. 3) Anti-receptor antibodies play an important role in the patho­genesis of Graves' disease, myasthenia gravis and insuline resistance. 4) Specificity spillover, where receptors of one hormone are stimulated by the excess amount of another hormone, is seen in galac­torrhea due to acromegaly, hyperthyroidism due to trophorcastic tumors, and in hypoglycemia accompanied non-islet cell tumors. 5) Abnormal receptor-effector coupling is recognized in pseudo­hypoparathyroidism due to deficiency of the nucleotide regulatory protein involved in adenylate cyclase activation. 
Keywords: Altered, Receptors
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Type of Study: Original | Subject: Interdisciplinary (Educational Management, Educational research, Statistics, Medical education
Received: 1988/04/30 | Accepted: 1988/11/3 | Published: 1989/04/27

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