Volume 49, Issue 3 (12-2025)
Research in Medicine 2025, 49(3): 0-0 |
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Rahimi R, Shahzamani K, Sabzali S, Birjandi M, Zavari T. Prevalence of HIV Comorbidities and Association with CD4+ Cell Counts Among HIV-Positive Individuals Covered by Khorramabad Counseling Centers (2010-2023). Research in Medicine 2025; 49 (3)
URL: http://pejouhesh.sbmu.ac.ir/article-1-3489-en.html
URL: http://pejouhesh.sbmu.ac.ir/article-1-3489-en.html
, tabassomzavari2@gmail.com
Abstract: (8 Views)
Background and Aim: Opportunistic and concomitant infections are considered one of the most important causes of mortality and reduced quality of life in HIV-positive patients. This study was designed to determine the prevalence of important concomitant infections of HIV disease and investigate their associated factors, with special emphasis on the relationship between CD4 lymphocyte levels, in the population of patients covered by Khorramabad counseling centers.
Methods: In this cross-sectional-analytical study, the medical records of 300 HIV-positive patients referred to behavioral disease counseling centers in Khorramabad between 2011 and 2023 were reviewed. In this study, the lowest recorded level of CD4+ T-cells and the most recent count for each patient were extracted and analyzed. Data were analyzed using SPSS software version 24 and using Chi-square and Fisher's exact test to examine the relationship between qualitative variables and CD4 levels. A significance level of (P<0.05) was considered.
Results: The results showed that 36.7% had PCP, 10.7% had HCVAb, 4% had overt tuberculosis, 4.7% had PPD test with a response of 5 cm or greater, 1% had TOXO IgG Ab positive. There was a significant relationship between the number of CD4 cells and PCP (P<0.001). However, there was no significant relationship with tuberculosis, hepatitis B and C, and Toxoplasma.
Conclusion: it seems that in the studied population, very low CD4 levels are associated with an increased risk of developing PCP. These results emphasize the importance of targeted prophylaxis and screening for PCP in patients with severe immunodeficiency.
Methods: In this cross-sectional-analytical study, the medical records of 300 HIV-positive patients referred to behavioral disease counseling centers in Khorramabad between 2011 and 2023 were reviewed. In this study, the lowest recorded level of CD4+ T-cells and the most recent count for each patient were extracted and analyzed. Data were analyzed using SPSS software version 24 and using Chi-square and Fisher's exact test to examine the relationship between qualitative variables and CD4 levels. A significance level of (P<0.05) was considered.
Results: The results showed that 36.7% had PCP, 10.7% had HCVAb, 4% had overt tuberculosis, 4.7% had PPD test with a response of 5 cm or greater, 1% had TOXO IgG Ab positive. There was a significant relationship between the number of CD4 cells and PCP (P<0.001). However, there was no significant relationship with tuberculosis, hepatitis B and C, and Toxoplasma.
Conclusion: it seems that in the studied population, very low CD4 levels are associated with an increased risk of developing PCP. These results emphasize the importance of targeted prophylaxis and screening for PCP in patients with severe immunodeficiency.
Type of Study: Original |
Subject:
Virology
Received: 2025/08/19 | Accepted: 2026/02/15 | Published: 2026/02/16
Received: 2025/08/19 | Accepted: 2026/02/15 | Published: 2026/02/16
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