Volume 49, Issue 3 (12-2025)
Research in Medicine 2025, 49(3): 21-29 |
Back to browse issues page
Ethics code: NA
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Rahimi R, Shahzamani K, Sabzali S, Birjandi M, Zavari T. Prevalence of HIV Comorbidities and Their Association with CD4+ Cell Counts among HIV- Positive Individuals Covered by Khorramabad Counseling Centers (2010-2023). Research in Medicine 2025; 49 (3) :21-29
URL: http://pejouhesh.sbmu.ac.ir/article-1-3489-en.html
URL: http://pejouhesh.sbmu.ac.ir/article-1-3489-en.html
Department of Tropical and Infectious Diseases, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran. , tabassomzavari2@gmail.com
Abstract: (197 Views)
Background and Aim: Opportunistic and concomitant infections are among the most important causes of mortality and reduced quality of life in HIV- positive patients. This study was designed to determine the prevalence of major concomitant infections in patients with HIV and to investigate their associated factors, with special emphasis on the relationship with CD4 lymphocyte levels, among patients covered by counseling centers in Khorramabad.
Methods: In this cross- sectional analytical study, the medical records of 300 HIV- positive patients referred to behavioral disease counseling centers in Khorramabad between 2011 and 2023 were reviewed. The lowest recorded CD4+ T-cell level and the most recent CD4 count for each patient were extracted and analyzed. Data were analyzed using SPSS software version 24. The Chi-square test and Fisher’s exact test were used to assess the relationship between qualitative variables and CD4 levels. A significance level of P < 0.05 was considered statistically significant.
Results: The findings showed that 36.7% of patients had Pneumocystis pneumonia (PCP), 10.7% were positive for HCV antibodies (HCVAb), 4% had overt tuberculosis, 4.7% had a PPD test response of 5 mm or greater, and 1% were positive for Toxoplasma IgG antibodies. A significant association was observed between CD4 cell count and PCP
(P < 0.001). However, no significant relationship was found between CD4 count and tuberculosis, hepatitis B or C, or toxoplasmosis.
Conclusion: In the studied population, very low CD4 levels were associated with an increased risk of developing PCP. These findings highlight the importance of targeted prophylaxis and regular screening for PCP in patients with severe immunodeficiency.
Methods: In this cross- sectional analytical study, the medical records of 300 HIV- positive patients referred to behavioral disease counseling centers in Khorramabad between 2011 and 2023 were reviewed. The lowest recorded CD4+ T-cell level and the most recent CD4 count for each patient were extracted and analyzed. Data were analyzed using SPSS software version 24. The Chi-square test and Fisher’s exact test were used to assess the relationship between qualitative variables and CD4 levels. A significance level of P < 0.05 was considered statistically significant.
Results: The findings showed that 36.7% of patients had Pneumocystis pneumonia (PCP), 10.7% were positive for HCV antibodies (HCVAb), 4% had overt tuberculosis, 4.7% had a PPD test response of 5 mm or greater, and 1% were positive for Toxoplasma IgG antibodies. A significant association was observed between CD4 cell count and PCP
(P < 0.001). However, no significant relationship was found between CD4 count and tuberculosis, hepatitis B or C, or toxoplasmosis.
Conclusion: In the studied population, very low CD4 levels were associated with an increased risk of developing PCP. These findings highlight the importance of targeted prophylaxis and regular screening for PCP in patients with severe immunodeficiency.
Keywords: AIDS, CD4 lymphocyte count, Opportunistic infections, Tuberculosis, Pneumocystis jirovecii
Type of Study: Original |
Subject:
Virology
Received: 2025/08/19 | Accepted: 2026/02/15 | Published: 2026/02/16
Received: 2025/08/19 | Accepted: 2026/02/15 | Published: 2026/02/16
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
This Journal is licensed under a Creative Commons Attribution 4.0 International License | Research in Medicine
Designed & Developed by : Yektaweb